Results 131 to 140 of about 834,176 (358)

Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain [PDF]

, 2020
Wesley L. Cai, Celeste B. Greer, Jocelyn F. Chen, Anna Arnal Estape, Jian Cao, Qin Yan, Don X. Nguyen   +6 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities [PDF]

, 2023
Yenan Yang, Chonghui Li, Ziyin Chen, Yiyang Zhang, Qing Tian, Meiling Sun, Shuai Zhang, Miao Yu, Gang Wang   +8 more
openalex   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]

, 2018
Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A, Vondriska, Thomas M, Wang, Yibin   +2 more
core  

Expanded Potential Stem Cells from Human Embryos Have an Open Chromatin Configuration with Enhanced Trophoblast Differentiation Ability [PDF]

, 2023
Andy Chun Hang Chen, Yin Lau Lee, Hanzhang Ruan, Wen Huang, Sze Wan Fong, Siyu Tian, Kai Chuen Lee, Genie Minju Wu, Yongqi Tan, Timothy Chun Hin Wong, Jian Wu, Weiyu Zhang, Dandan Cao, Judy Fung Cheung Chow, Pengtao Liu, William S.B. Yeung   +15 more
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Immunogenic cell death and immunogenic surrender: related but distinct mechanisms of immune surveillance

Cell Death and Disease, 2021
Rosanna Mezzapelle, Marco E. Bianchi, Massimo P. Crippa   +2 more
doaj   +1 more source

Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1

Nature Communications
The histone H2A variant H2A.W occupies transposons and thus prevents access to them in Arabidopsis thaliana. H2A.W is deposited by the chromatin remodeler DDM1, which also promotes the accessibility of chromatin writers to heterochromatin by an unknown ...
Akihisa Osakabe, Yoshimasa Takizawa, Naoki Horikoshi, Suguru Hatazawa, Lumi Negishi, Shoko Sato, Frédéric Berger, Tetsuji Kakutani, Hitoshi Kurumizaka   +8 more
doaj   +1 more source

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Molecular Systems Biology, 2019
In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis.
Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe   +21 more
doaj   +1 more source