Results 141 to 150 of about 496,209 (318)

Strand pairing by Rad54 and Rad51 is enhanced by chromatin [PDF]

, 2002
Vassilios Alexiadis, James T. Kadonaga
openalex   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

Advanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li, Chen Wu, Yuqi Zhu, Zicheng Liu, Wenjuan Yu, Andrew Lukwaro, Yu Zhong, Guoqiang Xie, Lili Zhou, Xiaoru Huang, Hui‐yao Lan, Junzhe Chen, Ying Tang   +12 more
wiley   +1 more source

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair [PDF]

, 2017
Justin Leung, Nodar Makharashvili, P. K. Agarwal, Li-Ya Chiu, Renaud Pourpre, Michael B. Cammarata, Joe R. Cannon, Alana Sherker, Daniel Durocher, Jennifer S. Brodbelt, Tanya T. Paull, Kyle M. Miller   +11 more
openalex   +1 more source

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Advanced Science, EarlyView.
The loss of NFS1 leads to its reduced binding with the transcription factor SP2, resulting in decreased expression of the downstream gene Idh2. This causes a shift in energy supply toward glycolysis in VSMCs, ultimately contributing to the occurrence and progression of AAA.
Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue   +9 more
wiley   +1 more source

DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder. [PDF]

Epigenetics Chromatin
Han VX, Patel S, Mohammad SS, Dale RC.
europepmc   +1 more source

Chromatin Unfolds [PDF]

Cell, 1996
openaire   +2 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

How ATP-Dependent Chromatin Remodeling Complexes Regulate Vertebrate Embryonic Development. [PDF]

Int J Mol Sci
Wang H, Anwaier G, Bai S, Liao L, Wang Y, Li S.   +5 more
europepmc   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Compaction of chromatin domains regulates target search times of proteins. [PDF]

PLoS Comput Biol
Dutta S, Rajakumar A, Padinhateeri R, Mitra MK.   +3 more
europepmc   +1 more source