Multiscale Modeling Primer: Focus on Chromatin and Epigenetics [PDF]
arXivEssential life processes take place across multiple space and time scales in living organisms but understanding their mechanistic interactions remains an ongoing challenge. Advanced multiscale modeling techniques are providing new opportunities and insights into these complex processes.
arxiv
OBSERVATIONS ON A GRANULE ASSOCIATED WITH CHROMATIN IN THE NUCLEI OF CELLS OF RAT AND MOUSE [PDF]
, 1962 Michael L. Watson
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Advanced Science, EarlyView.Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang +17 more
wiley +1 more source
Effect of growth hormone on ribonucleic acid metabolism. The template activity of the chromatin and molecular species of ribonucleic acid synthesized after treatment with the hormone [PDF]
, 1968 S. L. Gupta, G. P. Talwar
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Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells
Advanced Science, EarlyView.Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang +20 more
wiley +1 more source
Increased template activity of liver chromatin, a result of hydrocortisone administration. [PDF]
, 1965 Michael Dahmus, James Bonner
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Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy
Advanced Science, EarlyView.This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan +11 more
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The Behaviour of the Chromatin in the Meiotic Divisions of Vicia Faba
, 1914 MRS. GWYNNE-VAUGHAN H. C. I. FRASER
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Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
Advanced Science, EarlyView.Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He +6 more
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Advanced Science, EarlyView.RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong +13 more
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