Results 151 to 160 of about 834,176 (358)

Multiple structures of RNA polymerase II isolated from human nuclei by ChIP-CryoEM analysis

Nature Communications
RNA polymerase II (RNAPII) is a central transcription enzyme that exists as multiple forms with or without accessory factors, and transcribes the genomic DNA packaged in chromatin.
Tomoya Kujirai, Junko Kato, Kyoka Yamamoto, Seiya Hirai, Takeru Fujii, Kazumitsu Maehara, Akihito Harada, Lumi Negishi, Mitsuo Ogasawara, Yuki Yamaguchi, Yasuyuki Ohkawa, Yoshimasa Takizawa, Hitoshi Kurumizaka   +12 more
doaj   +1 more source

Rupture Dynamics and Chromatin Herniation in Deformed Nuclei [PDF]

, 2017
Dan Deviri, Dennis E. Discher, S. A. Safran   +2 more
openalex   +1 more source

Interpretable deep learning for chromatin-informed inference of transcriptional programs driven by somatic alterations across cancers [PDF]

, 2022
Yifeng Tao, Xiaojun Ma, Drake Palmer, Russell Schwartz, Xinghua Lu, Hatice U. Osmanbeyoglu   +5 more
openalex   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

The synergistic action of HDAC inhibitor with cisplatin impedes survival and proliferation of drug-tolerant persister in gastric and liver cancer cells

Clinical Epigenetics
Acquired therapy resistance is a dynamic process associated with early epigenetic modifications reshaping gene transcription across multiple cellular pathways, ultimately giving rise to drug-tolerant persister (DTP) cells.
Anjali Singh, Abhiram Natu, Flevia Anthony, Hemalatha Muthu, Bharat Khade, Duane T. Smoot, Hassan Ashktorab, Sanjay Gupta   +7 more
doaj   +1 more source

The semisynthesis of site-specifically modified histones and histone-based probes of chromatin-modifying enzymes [PDF]

, 2023
Madeline F. Currie, Sumeet K. Singh, Meihuan Ji, Champak Chatterjee   +3 more
openalex   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution

, 2020
Qiancheng You, Anthony Cheng, Xi Gu, Bryan T. Harada, Miao Yu, Tong Wu, Bing Ren, Zhengqing Ouyang, Chuan He   +8 more
openalex   +2 more sources

SEX CHROMATIN [PDF]

Journal of Medical Genetics, 1964
openaire   +2 more sources

Differentiation Treatment Applied to Lung Cancer Model Reduces Pathogenic Traits in Vitro

Advanced Biology, EarlyView.
Non‐small cell lung cancer cells (A549) treated with a differentiation medium showed strong reduction in proliferation, migration, clonogenicity, spheroid formation and stemness markers, with enhanced adhesion properties and alveolar features, all pointing to a notably less aggressive phenotype in support of differentiation therapy as a promising ...
Alice Grossi, Paola Fulghieri, Abdurakhmon Aduvaliev, Karen Soffiantini, Irene Oldrati, Margherita Cavallo, Marco Biggiogera, Giorgia Pellavio, Umberto Laforenza, Monica Savio, Virginie Sottile   +10 more
wiley   +1 more source