Results 151 to 160 of about 995,221 (398)
The Sex Chromatin in Benign Tumours and Related Conditions in Man [PDF]
, 1955 Keith L. Moore, Murray L. Barr
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Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture. [PDF]
, 2018 Epigenetic processes are known to have powerful roles in organ development across biology. It has recently been found that some of the chromatin modulatory machinery essential for proper development plays a previously unappreciated role in the ...
McKinsey, Timothy A +2 more
core
Most autophagic cell death studies lack evidence of causality
FEBS Open Bio, EarlyView.Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley +1 more source
Nature Genetics, 2016 We define the chromatin accessibility and transcriptional landscapes in 13 human primary blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the enhancer landscape better reflects cell identity than mRNA levels, we enable '
M. Corces +13 more
semanticscholar +1 more source
The Individuality of Nuclear Chromatin with Particular Reference to Polymorphonuclear Neutrophil Leukocytes [PDF]
, 1958 Donald K. Briggs
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FEBS Open Bio, EarlyView.Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu +6 more
wiley +1 more source
ISOLATION OF CHROMATIN THREADS FROM THE RESTING NUCLEUS OF LEUKEMIC CELLS [PDF]
, 1943 Albert Claude, James S. Potter
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FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Nature Communications, 2018 Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions.
Stephen J. Clark +11 more
semanticscholar +1 more source
Nucleosome spacing can fine-tune higher-order chromatin assembly
Nature CommunicationsCellular chromatin displays heterogeneous structure and dynamics, properties that control diverse nuclear processes. Models invoke phase separation of conformational ensembles of chromatin fibers as a mechanism regulating chromatin organization in vivo ...
Lifeng Chen +10 more
doaj +1 more source