Results 151 to 160 of about 452,870 (322)
bioSBM: a random graph model to integrate epigenomic data in chromatin structure prediction [PDF]
arXivThe spatial organization of chromatin within the nucleus plays a crucial role in gene expression and genome function. However, the quantitative relationship between this organization and nuclear biochemical processes remains under debate. In this study, we present a graph-based generative model, bioSBM, designed to capture long-range chromatin ...
arxiv
URIDINE-5-H3 RADIOAUTOGRAPHY OF THE HUMAN SEX CHROMATIN BODY [PDF]
, 1966 David E. Comings
openalex +1 more source
A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer
Advanced Science, EarlyView.The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang +6 more
wiley +1 more source
Landscapes and nonequilibrium fluctuations of eukaryotic gene regulation [PDF]
arXivUnderstanding the interplay among processes that occur over different timescales is a challenging issue in the physics of systems regulation. In gene regulation, the timescales for changes in chromatin states can differ from those for changes in the concentration of product protein, raising questions about how to understand their coupled dynamics.
arxiv
Stimulation of hen erythrocyte chromatin by extracts of rat liver or uterus [PDF]
, 1969 R E Leake, J. M. Barry
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Advanced Science, EarlyView.USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang +16 more
wiley +1 more source
Advanced Science, EarlyView.This study utilized Ss‐STARR‐seq to construct a genome‐wide silencer map of mouse cells and elucidated the fundamental characteristics of these silencers. These silencers exist in a cell‐specific manner and exhibit unique epigenetic modifications. Through functional experiments, we also discovered that these silencers can regulate gene expression and ...
Xiusheng Zhu +12 more
wiley +1 more source
Chromatin-Melanin Relationships in Malignant Melanomata1
, 1951 E. Meirowsky, L. W. Freeman
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Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced Science, EarlyView.This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao +15 more
wiley +1 more source
A Novel Role for Kruppel-like Factor 14 (KLF14) in T-Regulatory Cell DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2015 Background & Aims: Kruppel-like Factor 14 (KLF14) proteins function as epigenetic reprogramming factors during cell differentiation in many cell populations and in engineered induced pluripotent stem cells.
Olga F. Sarmento +8 more
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