Results 171 to 180 of about 834,176 (358)

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

The single-cell chromatin accessibility landscape in mouse perinatal testis development

, 2023
Hoi Ching Suen, Shitao Rao, Alfred Chun Shui Luk, Ruoyu Zhang, Lele Yang, Huayu Qi, Hon‐Cheong So, Robin M. Hobbs, TL Lee, Jinyue Liao   +9 more
openalex   +1 more source

Femtosecond‐Laser‐Fabricated 3D CYTOP Microfluidic Chips Enabling Super‐Resolution Live Imaging of Cell Behavior in Confined Microspaces

Advanced Materials Technologies, EarlyView.
Using two‐photon polymerization of SU‐8 together with mold processing allowed the creation of defect‐free, flexible 3D microfluidic structures with sub‐micrometer precision in CYTOP. The fabricated CYTOP microfluidic chips enabled super‐resolution imaging of cancer cells in the microchannels, clearly visualizing previously undetectable fine structural ...
Koji Sugioka, Mirai Hanzawa, Kotaro Obata, Sota Matsumoto, Masatoshi Takagi, Asako Sakaue‐Sawano, Asako Tosaki, Satoshi Shimozono, Felix Sima, Hiroyuki Kawano, Takuro Tojima, Daisuke Miyashiro, Kazunari Ozasa, Yasutaka Hanada, Godai Miyaji, Akihiko Nakano, Atsushi Miyawaki   +16 more
wiley   +1 more source

Comparison of spatial transcriptomics technologies using tumor cryosections

Genome Biology
Background Spatial transcriptomics technologies are revolutionizing our understanding of intra-tumor heterogeneity and the tumor microenvironment by revealing single-cell molecular profiles within their spatial tissue context.
Anne Rademacher, Alik Huseynov, Michele Bortolomeazzi, Sina Jasmin Wille, Sabrina Schumacher, Pooja Sant, Denise Keitel, Konstantin Okonechnikov, David R. Ghasemi, Kristian W. Pajtler, Jan-Philipp Mallm, Karsten Rippe   +11 more
doaj   +1 more source

Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in β-cells

, 2008
Michael C. Lawrence, Kathleen McGlynn, Chunli Shao, Lingling Duan, Bashoo Naziruddin, Marlon F. Levy, Melanie H. Cobb   +6 more
openalex   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Single-cell chromatin landscapes of mouse skin development [PDF]

, 2022
Fang Li, Tiantian Xu, Jiale Li, Xuxu Hao, Wei Ge, Xin Wang   +5 more
openalex   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Chromatin structure restricts origin utilization when quiescent cells re-enter the cell cycle [PDF]

, 2020
Po-Hsuen Lee, Mary Ann Osley
openalex   +1 more source