Results 171 to 180 of about 452,870 (322)

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou, Yan Guo, Shuang Xu, Mi Bai, Weidong Cao, Yue Zhang, Zhanjun Jia, Aihua Zhang   +7 more
wiley   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Advanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar‐Nur, Johan Auwerx, Martin Wohlwend   +6 more
wiley   +1 more source

Disruption of FOXP3–EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal InflammationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Forkhead box protein 3 (FOXP3)+ regulatory T cell (Treg) dysfunction is associated with autoimmune diseases; however, the mechanisms responsible for inflammatory bowel disease pathophysiology are poorly understood.
Adebowale O. Bamidele, Phyllis A. Svingen, Mary R. Sagstetter, Olga F. Sarmento, Michelle Gonzalez, Manuel B. Braga Neto, Subra Kugathasan, Gwen Lomberk, Raul A. Urrutia, William A. Faubion, Jr.   +9 more
doaj  

Finger and palm prints in chromatin-positive males. [PDF]

, 1968
Henry Hunter
openalex   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

THE ABILITY OF DNA AND CHROMATIN OF DEVELOPING FROG EMBRYOS TO PRIME FOR RNA POLYMERASE-DEPENDENT RNA SYNTHESIS [PDF]

, 1965
R.A. Flickinger, S. J. Coward, M. Miyagi, Christina Möser, E. Rollins   +4 more
openalex   +1 more source

Cryo-EM Structures of Native Chromatin Units From Human Cells. [PDF]

Genes Cells
Hatazawa S, Fukuda Y, Kobayashi Y, Negishi L, Kikkawa M, Takizawa Y, Kurumizaka H.   +6 more
europepmc   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

HETEROCHROMATIN AND GENETIC ACTIVITY IN MEALY BUGS I. COMPENSATION FOR INACTIVE CHROMATIN BY INCREASE IN CELL NUMBER [PDF]

, 1968
Laurence Berlowitz, Mary W. Loewus, Dominick Pallotta   +2 more
openalex   +1 more source

Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression. [PDF]

Nat Commun
Vinayak V, Basir R, Golloshi R, Toth J, Sant'Anna L, Lakadamyali M, McCord RP, Shenoy VB.   +7 more
europepmc   +1 more source