Results 201 to 210 of about 834,176 (358)

Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation. [PDF]

Sci Adv
Wang Z, Dong W, Feng X, Xu X, An Y, Xiao H, Luo M, Liang Q, Bai R, Zhao K, Wu L, Zhao L, Zhou Y, Yi X, Huang D, Sengupta K, Plewczynski D, Sham PC, Liu C, Yu Y, Li W, Gong Q, Song W, Zhou W, Li MJ.   +24 more
europepmc   +1 more source

Cytology of DNA Replication Reveals Dynamic Plasticity of Large-Scale Chromatin Fibers

, 2016
Xiang Deng, Oxana A. Zhironkina, Varvara D. Cherepanynets, Olga Strelkova, Igor I. Kireev, Andrew S. Belmont   +5 more
openalex   +2 more sources

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Dynamic architecture of mammalian paternal chromatin: histone-to-protamine exchange and post-fertilization reprogramming. [PDF]

Epigenetics Chromatin
Firouzabadi AM, Fesahat F, Seifati SM.
europepmc   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Correction: Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression. [PDF]

Epigenetics Chromatin
Li Y, Wang L, Wanga W, Wangb W, Huang W, Liu S.   +5 more
europepmc   +1 more source

Characterization of a Novel Chromatin Sorting Tool Reveals Importance of Histone Variant H3.3 in Contextual Fear Memory and Motor Learning [PDF]

, 2016
Anna G. McNally, Shane G. Poplawski, Brittany A. Mayweather, Kyle White, Ted Abel   +4 more
openalex   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

Recent advances in single-cell bioinformatics for inferring higher-order chromatin contact maps. [PDF]

BMB Rep
Noh SK, Lee M, Jeong H.
europepmc   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source