Results 251 to 260 of about 496,209 (318)

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Dynamic architecture of mammalian paternal chromatin: histone-to-protamine exchange and post-fertilization reprogramming. [PDF]

Epigenetics Chromatin
Firouzabadi AM, Fesahat F, Seifati SM.
europepmc   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation. [PDF]

Sci Adv
Wang Z, Dong W, Feng X, Xu X, An Y, Xiao H, Luo M, Liang Q, Bai R, Zhao K, Wu L, Zhao L, Zhou Y, Yi X, Huang D, Sengupta K, Plewczynski D, Sham PC, Liu C, Yu Y, Li W, Gong Q, Song W, Zhou W, Li MJ.   +24 more
europepmc   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Reviewer #2 (Public review): Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

Haihui Zhang, Zhengyang Lei, Fatemeh Momen-Heravi, Peiwu Qin   +3 more
openalex   +1 more source

Enhancer Trajectories in Lineage Commitment: Regulatory Logic of States and Cooperation. [PDF]

Biomolecules
Oh M, Jeong S, Kang K, Kim SK.
europepmc   +1 more source

Metabolic regulation by the chromatin remodeler Ino80 under stress conditions and improvement of yeast stress tolerance for efficient bioproduction

Bo Yuan, Wentao Wang, Xixi Zhao
openalex   +1 more source

An anti-inflammatory autophagic target in chronic diseases. [PDF]

Cell Res
Akepati PR, Deretic V.
europepmc   +1 more source

Reviewer #2 (Public review): Chromatin activity of IκBα mediates the exit from naïve pluripotency

Luis G Palma, Daniel Álvarez-Villanueva, María Maqueda, Mercedes Barrero, Arnau Iglesias, Joan Bertran, Damiana Álvarez-Errico, Carlos A García-Prieto, Cecilia Ballaré, Virginia Rodriguez-Cortez, Clara Bueno, August Vidal, Alberto Villanueva, Pablo Menéndez, Gregoire Stik, Luciano Di Croce, Bernhard Payer, Manel Esteller, Lluís Espinosa, Anna Bigas   +19 more
openalex   +1 more source