Results 261 to 270 of about 995,221 (398)

3D Genome Architecture in Stem Cell Lineage Commitment: from Structural Organization to Precision Regulation. [PDF]

Adv Genet (Hoboken)
He Y, Li W, Li L, Yang Y, Lu Y, Pan Y, Wang Q, Sun Y, Xie Y, Wu M, Luo P, Sun W, Zhang H.   +12 more
europepmc   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

Clinical Application of Sex Chromatin Tests [PDF]

, 1967
A. I. Taylor
openalex   +1 more source

Targeting chromatin remodeling complexes to treat uveal melanoma. [PDF]

Elife
Nilsson JA.
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

STUDIES ON SEX CHROMATIN

, 1966
M Hikita
openalex   +2 more sources

The Biological Function of Genome Organization. [PDF]

Int J Mol Sci
Yang X, Zhu H, Liu Y, Wang J, Song Y, Liao S, Dong P.   +6 more
europepmc   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

Organization of Chromatin by Intrinsic and Regulated Phase Separation

Cell, 2019
Bryan A. Gibson, L. Doolittle, Maximillian W.G. Schneider, Liv E. Jensen, Nathan Gamarra, L. Henry, D. Gerlich, S. Redding, M. Rosen   +8 more
semanticscholar   +1 more source

ACTIVE AND INACTIVE REGIONS OF NUCLEAR CHROMATIN AS REVEALED BY ELECTRON MICROSCOPE AUTORADIOGRAPHY

, 1964
Virginia C. Littau, V. G. Allfrey, John H. Frenster, A. E. Mirsky   +3 more
openalex   +1 more source