Results 291 to 300 of about 834,176 (358)

Epigenetic Editing in Neurological and Neuropsychiatric Disorders: Pioneering Next-Gen Therapeutics for Precision Gene Control. [PDF]

Mol Neurobiol
Marei HE.
europepmc   +1 more source

Positive Feedback Loop of Histone Lactylation‐Driven HNRNPC Promotes Autophagy to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

Advanced Science, EarlyView.
Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang, Jiao Chen, En‐Liang Zhu, Ming‐Jian Ma, Yang‐Yin‐Hui Yu, Ying‐Qin Zhu, Jing‐Yuan Ye, Jin‐Zhao Xie, Zi‐Yi Zhao, Xiao‐Yu Yin   +9 more
wiley   +1 more source

Chromatin accessibility in stem cells unveils progressive transcriptional alterations in myelodysplastic syndrome. [PDF]

Nat Commun
Oshima M, Takayama N, Nakajima-Takagi Y, Shinoda D, Itokawa N, Kurosawa S, Kaito S, Kamiya T, Yamada Y, Andoh S, Kayamori K, Paul SK, Kanashiro MA, Muto T, Tsukamoto S, Sakaida E, Sato E, Yusa N, Yokoyama K, Nannya Y, Imoto S, Rahmutulla B, Kaneda A, Yamaguchi K, Furukawa Y, Doki N, Eto K, Nishikawa K, Ding Y, Myojo T, Harada Y, Harada H, Iwama A.   +32 more
europepmc   +1 more source

Chromatin accessibility variation provides insights into missing regulation underlying immune-mediated diseases. [PDF]

Elife
Jeong R, Bulyk ML.
europepmc   +1 more source

Epigenetic Regulation of Floral Transition. [PDF]

Plants (Basel)
Li Y, Zhang D, Wang J, Yang M, Yin Z, Zhu K, Liang Y, Tan X.   +7 more
europepmc   +1 more source

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

Russell K, Chen Y, Espinosa JR, Gil DF, Zhou H, Maristany MJ, Lopez JIP, Huertas J, Orozco M, Rosen MK, Collepardo-Guevara R.   +10 more
europepmc   +1 more source

Condensin chromatin association is regulated by SMC head and hinge engagement and phosphorylation

Miles CA, Yu M, Minchell NE, Schalbetter SA, Oliver AW, Sweet SM, Baxter J.   +6 more
europepmc   +1 more source