Results 311 to 320 of about 971,786 (390)

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Cold-induced nucleosome dynamics linked to silencing of Arabidopsis FLC. [PDF]

Nat Commun
Montez M, Zhu D, Huertas J, Maristany MJ, Rutjens B, Nielsen M, Collepardo-Guevara R, Dean C.   +7 more
europepmc   +1 more source

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Insulator BEAF32 regulates expression of tissue-specific genes and piRNA source loci in Drosophila ovaries. [PDF]

Epigenetics Chromatin
Kobelyatskaya AA, Morgunova V, Kalinkin A, Shchukina AA, Sokolova O, Kwon DA, Funikov S, Kalmykova A.   +7 more
europepmc   +1 more source

INFLUENCE OF PHYSICAL STATE OF CHROMATIN ON NUCLEIC ACID AND PROTEIN SYNTHESIS AND ON RADIATION SENSITIVITY OF CELL DIVISION. Comprehensive Report, June 1, 1966--August 31, 1969.

, 1969
Mary Esther Gaulden
openalex   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Electron microscopic and biochemical evidence that chromatin structure is a repeating unit

, 1975
P Oudet, M. Gross-Bellard, Pierre Chambon   +2 more
openalex   +1 more source

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

Clonorchis sinensis infection remodels chromatin accessibility in hepatocellular carcinoma. [PDF]

Parasit Vectors
Yang W, Wei C, Chen J, Lin Q, Qin Y, Huang T, Deng X, Li MJ, Tang Z, Fang M.   +9 more
europepmc   +1 more source

Different accessibilities in chromatin to histone acetylase.

, 1979
Lawrence S. Cousens, Dieter Gallwitz, Bruce Alberts   +2 more
openalex   +1 more source