Results 311 to 320 of about 995,221 (398)

Extracts of Drosophila embryos mediate chromatin assembly in vitro.

, 1979
Timothy Nelson, T S Hsieh, Douglas L. Brutlag   +2 more
openalex   +1 more source

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation. [PDF]

Nat Commun
Zhang H, Li Z, Zhu Y, Lyu W, Wei W, Wang H, Tian S, Yue W, Zhong J, Sun QY, Guan Y.   +10 more
europepmc   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

3D Genome Engineering: Current Advances and Therapeutic Opportunities in Human Diseases. [PDF]

Research (Wash D C)
Jiang X, Wang X, Shen S, Hou S, Yu C.
europepmc   +1 more source

Super‐Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation

Advanced Science, EarlyView.
A novel chromatin‐labeling probe is developed to investigate chromatin mobility during differentiation. The silicon rhodamine–conjugated dCTP is efficiently delivered into iPSCs and NSCs using a synthetic transporter. Super‐resolution microscopy and single‐particle tracking show decreased chromatin mobility during differentiation.
Maruthi K. Pabba, Miroslav Kuba, Tomáš Kraus, Kerem Celikay, Janis Meyer, Sunil Kumar Pradhan, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Karl Rohr, Michal Hocek, M. Cristina Cardoso   +11 more
wiley   +1 more source

Modelling transcriptional silencing and its coupling to 3D genome organisation.

Soft Matter
Semeraro M, Negro G, Marenduzzo D, Forte G.   +3 more
europepmc   +1 more source

Heterogeneity as a feature: unraveling chromatin's role in nuclear mechanics. [PDF]

Nucleus
Rodenburg WS, Strom AR, Eeftens JM.
europepmc   +1 more source

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science, EarlyView.
This study identifies that RBM10 represses the transcriptional activity of RORB in liquid condensates, resulting in down‐regulation of NR1D1 and RIOK3 that further activates NF‐κB activity to facilitate lysosomal biogenesis and aggressive features of NB cells.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
wiley   +1 more source

Multi-omics integration reveals Chr1 associated QTL mediating backfat thickness in pigs. [PDF]

J Anim Sci Biotechnol
Yu N, Cui D, Li C, Yang S, Qiao C, Xie L.   +5 more
europepmc   +1 more source

Vinburnine Sensitizes Radiotherapy Efficacy in Nasopharyngeal Carcinoma by Triggering Pyroptosis and Immune Responses via Activation of EDAR‐NFκB Pathway

Advanced Science, EarlyView.
This study demonstrates that vinburnine, an approved cerebrovascular drug, synergizes with radiotherapy in nasopharyngeal carcinoma (NPC) by modulating EDAR‐NFκB signaling through directly binding to EDAR, leading to triggering apoptosis/pyroptosis, and amplifying CCL5/CX3CL1‐driven T‐cell cytotoxicity.
Jing Chen, Nian Liu, Qian Tao, Jie Wu, Jinyu Huang, Can Lu, Qiuqiu Li, Liangfang Shen, Xiang Chen, Cong Peng   +9 more
wiley   +1 more source