Results 341 to 350 of about 971,786 (390)

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS. [PDF]

Nucleic Acids Res
Poovathumkadavil D, Reynolds-Winczura A, Skagia A, Passaretti P, Sadurni MM, Kingsley G, Leitner A, Saponaro M, Gambus A.   +8 more
europepmc   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

A multi-omic single-cell landscape reveals transcription and epigenetic regulatory features of t(8;21) AML. [PDF]

J Transl Med
Li XP, Gao Y, Zhao BT, Dai YT, Mao JY, Liang Y, Jiang L.   +6 more
europepmc   +1 more source

NuclampFISH enables cell sorting based on nuclear RNA expression for chromatin analysis. [PDF]

BMC Genomics
Liu Y, Qiu Y, Nian K, Rouhanifard SH.
europepmc   +1 more source

Genome-wide identification of the H3K27ac signals reveals key thermogenic cis-regulatory elements of brown adipose tissues in Oryctolagus cuniculus. [PDF]

BMC Genomics
Du K, Wu Q, Gan YX, Tang XY, Zan JX, Sun WQ, Luo G, Chen XW, Wang DH.   +8 more
europepmc   +1 more source

YEATS2 O-GlcNAcylation promotes chromatin association of the ATAC complex and lung cancer tumorigenesis. [PDF]

J Biol Chem
Zhao J, Zhao Z, Zhou W, Zhang J, Chen J, Sun J, Li J.   +6 more
europepmc   +1 more source

IFI16 Mediates Deacetylation of KSHV Chromatin via Interaction with NuRD and Sin3A Co-Repressor Complexes. [PDF]

Viruses
Ghosh A, Chandran B, Roy A.
europepmc   +1 more source

Remodeling Activity of ChAHP Restricts Transcription Factor Access to Chromatin

Ahel J, Mohn F, Schwaiger M, Kaaij L, Steiner J, Moreno EPF, Hess D, Bühler M.   +7 more
europepmc   +1 more source