Results 341 to 350 of about 995,221 (398)
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Nature, 2012 The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete.
Jesse R Dixon +2 more
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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Nature Reviews Molecular Cell Biology, 2017 Arnab Ray Chaudhuri
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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Nature, 2007 Tarjei S Mikkelsen +2 more
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Synaptic, transcriptional and chromatin genes disrupted in autism
Nature, 2014 The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ...
Mark Joseph Daly +2 more
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Chromatin accessibility and the regulatory epigenome
Nature Reviews Genetics, 2019William J Greenleaf
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Critical Reviews in Biochemistry and Molecular Biology, 2012
Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation.
Ehrensberger AH, Svejstrup JQ
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Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation.
Ehrensberger AH, Svejstrup JQ
openaire +2 more sources
Extended chromatin fibers and chromatin organization
Biotechnic & Histochemistry, 2010Studies of chromatin extensibility have revealed the flow of chromatin and DNA from cell nuclei and chromosomes in response to gravity or mechanical stretch following lysis by hypertonic saline and detergent solutions. Since this phenomenon was first reported, the technical methods by which extended chromatin fibers (ECFs) may be analyzed have been ...
Alberto S. Moraes +2 more
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Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Nature Reviews Molecular Cell Biology, 2017Janet H Iwasa +2 more
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Nature, 1978
The approximate shape of the chromatin subunit called the nucleosome is now known, but its internal architecture is not well understood. Recent studies reveal details of the organisation of DNA within the nucleosome, and show that the arginine-rich histones are essential to DNA folding.
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The approximate shape of the chromatin subunit called the nucleosome is now known, but its internal architecture is not well understood. Recent studies reveal details of the organisation of DNA within the nucleosome, and show that the arginine-rich histones are essential to DNA folding.
openaire +2 more sources