Results 191 to 200 of about 729,544 (290)

Atranone-an underestimated secondary metabolite? [PDF]

Mycotoxin Res
Dabisch-Ruthe M, Pfannebecker J, Straubinger RK, Ebel F, Ulrich S.   +4 more
europepmc   +1 more source

LDI, A Lipid Droplet Inhibitor, Disrupts Lipid Accumulation and Modulates Hepatic Lipid Profiles in Fatty Liver

Advanced Materials, EarlyView.
The lipid droplet inhibitor (LDI), templated with large‐pore mesoporous silica and functionalized with PKCα C1A and lipase, targets lipid degradation in fatty liver. The LDI maintains stable association with lipid droplets, thereby suppressing their formation and expansion.
Seunghee Kim, Yeojin Kim, Sanjita Paudel, In Young Kang, Suyeon Kim, Jeesoo Kim, Sunmi Park, Seung‐Hoi Koo, Hyun Sung Kim, Dae Won Jun, Jinyoung Park, Hyunbeom Lee, Joonseok Lee   +12 more
wiley   +1 more source

Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation

Advanced Materials, EarlyView.
 Shell‐engineered poly(alkyl cyanoacrylate) microbubbles with tunable stiffness improve ultrasound imaging and therapy. Adjusting the length of the alkyl chain and the glass transition temperature maintains a narrow microbubble size distribution while enhancing drug loading, sonoporation and the acoustic response.
Roman A. Barmin, MirJavad Moosavifar, Elena Rama, Julia Blöck, Anne Rix, Vladislav S. Petrovskii, Rustam A. Gumerov, Jens Köhler, Michael Pohl, Céline Bastard, Stephan Rütten, Laura Charlton, Vu Ngoc Khiêm, Fabio Domenici, Thomas Lisson, Ekaterina Savina, Rui Zhang, Jasmin Baier, Susanne Koletnik, Vasileios Koutsos, Mikhail Itskov, Gaio Paradossi, Georg Schmitz, Tina Vermonden, Laura De Laporte, Robert Göstl, Andreas Herrmann, Igor I Potemkin, Fabian Kiessling, Twan Lammers, Roger M. Pallares   +30 more
wiley   +1 more source

Competing Michael/Anti-Michael Addition of Silyl Ketene Acetals to β-Nitrostyrenes Incorporating an Electron-Withdrawing Group. [PDF]

J Org Chem
Martínez-Aguirre MA, Cruz-Aguilar DA, Hernández-Huerta E, López-Barba D, Ballinas-Indili R, Rosales-Amezcua SC, Álvarez-Toledano C, Hernández-Rodríguez M.   +7 more
europepmc   +1 more source

Supramolecular Interface Engineering via Interdiffusion for Reusable and Dismantlable Polymer Adhesion

Advanced Materials, EarlyView.
Reversible adhesion via host–guest complex formation at the polymer interface is achieved by externally controlling the complexation through applied stimuli. Neutron reflectometry analysis of the adhesion interface revealed that the presence of host–guest complexes hinders the polymer interdiffusion by despite promoting adhesion strength.
Kenji Yamaoka, Takuma Wada, Iori Ogasa, Takeru Komyo, Chao Luo, Ryohei Ikura, Masahiro Hino, Masako Yamada, Hideki Seto, Yoshihisa Fujii, Yasutomo Uetsuji, Yoshinori Takashima   +11 more
wiley   +1 more source

Development of triaryl antimicrobials by scaffold hopping from an aminopropanol hit targeting bacterial RNA polymerase-NusG interactions. [PDF]

J Enzyme Inhib Med Chem
Liu T, Kan CH, Zheng Y, Tsang TF, Liu Y, Tsang MW, Fang H, Lam LY, Yang X, Ma C.   +9 more
europepmc   +1 more source

Engineered Protein‐Based Ionic Conductors for Sustainable Energy Storage Applications

Advanced Materials, EarlyView.
Rational incorporation of charged residues into an engineered, self‐assembling protein scaffold yields solid‐state protein films with outstanding ionic conductivity. Salt‐doping further enhances conductivity, an effect amplified in the engineered variants. These properties enable the material integration into an efficient supercapacitor.
Juan David Cortés‐Ossa, Paolo Blesio, Marcial Fernandez‐Castro, Lisa Almonte, Maxence Fernandez, Mantas Liutkus, Perumal Pandurangan, Carlos Sabater, Aitor Villaverde, Manuel Melle‐Franco, Nurit Ashkenasy, Felipe Jiménez‐Ángeles, M. Carmen Morant‐Miñana, M. Reyes Calvo, Aitziber L. Cortajarena   +14 more
wiley   +1 more source

Purification and characterization of recombinant human translation initiation factor eIF3. [PDF]

Protein Sci
Diaz-Lopez I, Gordiyenko Y, Zuber PK, Li X, Ramakrishnan V.   +4 more
europepmc   +1 more source

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid‐Responsive Ketal Side Groups

Advanced Materials, EarlyView.
An acid‐responsive polymeric micelle system based of aliphatic poly(carbonate)s with benzyl ketal side chains is designed for targeted immunodrug delivery. It can disassemble in endosomal environments, enabling site‐specific immunoactivation and enhanced biodegradability.
Adrian V. Hauck, Michael Fichter, Laura J. Rosenberger, Jannis Willig, Alexander Fuchs, Felicia Schön, Paul Schneider, Carolina Medina‐Montano, Taufiq Ahmad, Jessica Erlenbusch, Pol Besenius, Leonard Kaps, Matthias Bros, Stephan Grabbe, Volker Mailänder, Jürgen Groll, Lutz Nuhn   +16 more
wiley   +1 more source

β-Acyloxyl alkenyl amide synthesis via multiple defluorination: α-Trifluoromethyl ketone-amine as synergystic peptide coupling reagent. [PDF]

Sci Adv
Cao S, Guo H, Zhong Z, Chen D, Song W, Liu Y, Wan JP.   +6 more
europepmc   +1 more source