Results 191 to 200 of about 410,509 (265)

Cyclization Reaction of α‑Hydroxyketones with Anthranilamides or 2‑Aminobenzenesulfonamides for the Synthesis of Quinazolinones and Benzothiadiazines. [PDF]

ACS Omega
Niu ZX, Zhang QY, Zhao XY, Sun HP, Wu ZW, Chao LL, Gao WY, Li H.   +7 more
europepmc   +1 more source

Robust and Thermally Stable Silicone Aerogels with Hyperconnected Network via Kinetically Optimized Hyperbranched Silane Precursors

Advanced Science, EarlyView.
Reactivity‐Programmed Assembly: A kinetic‐control strategy is reported for constructing hyperconnected silicone aerogels with a robust “thick‐neck” architecture. By exploiting the reactivity disparity of precursors, flexible segments are uniformly embedded within a rigid skeleton.
Aoqing Yan, Guixiang Li, Yaolan Li, Yi Luo, Bin Liu, Zhe Su, Hao Tian, Wei Shi, Bo Niu, Donghui Long   +9 more
wiley   +1 more source

Stereocontrolled Synthesis of Dimethylamino Phosphorochloridate Monomers toward Stereopure Phosphorodiamidate Morpholino Oligonucleotides. [PDF]

J Org Chem
Inutake R, Hasegawa H, Tsurusaki T, Sakamoto T, Sato K, Wada T.   +5 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Synthesis of Avenanthramide C and Its Analogs Utilizing Classical Condensation, Saponification and Acidification. [PDF]

ACS Omega
Choi SM, An YJ, Nam YE, Kwon SJ, Choi ER, Cho JH.   +5 more
europepmc   +1 more source

Toward Flexible Printed Electronics: A Spider‐Silk‐Inspired, Strong and Tough Thermoplastic Polyamide Elastomer

Advanced Science, EarlyView.
Inspired by spider silk, a bio‐inspired polyamide elastomer with a dynamic physical cross‐linking network is developed. Mimicking the rigid β‐sheet crystals and sacrificial hydrogen bonds of silk, the material achieves an exceptional balance of strength and toughness.
Bo Yang, Liyue Zhang, Mengjing Yang, Hangzhi Guo, Zhibo Lin, Xinyu Qi, Wenjun Li, Haiyan Yan, Meng Li, Yanhui Chen, Weixing Chen, Zhenguo Liu, Wei Huang   +12 more
wiley   +1 more source

Enhanced production of Nattokinase by Bacillus aryabhattai RP6 isolated from fermented Brassica oleracea. [PDF]

BMC Biotechnol
Prasanna R, Kundu D, Mohanan M, Vaithilingam M, Chandrasekaran SD.   +4 more
europepmc   +1 more source

A metabolite extracted from Escherichia coli suppresses tau aggregation. [PDF]

Biochem J
Srinivasan M, Patel A, Patel T, Moore J, Gomez-Cardona E, Yarahmady A, Sykes BD, Julien O, Mok SA.   +8 more
europepmc   +1 more source

Synthesis and Biological Profiling of New 1,2,3,4-Tetrahydrobenzo[<i>h</i>]naphthyridine-Based Hybrids as Dual Inhibitors of β-Amyloid and Tau Aggregation with Anticholinesterase Activity. [PDF]

Biomolecules
Verano AB, Sampietro A, Mallo-Abreu A, Spagnuolo R, Pérez B, Bartolini M, Loza MI, Brea J, Juárez-Jiménez J, Sabate R, Galdeano C, Muñoz-Torrero D.   +11 more
europepmc   +1 more source

Synthesis and Cytotoxicity of Complex Betulinic Acid Amides. [PDF]

ACS Omega
Wimmerová M, Kyjaková P, Šaman D, Wimmer Z.   +3 more
europepmc   +1 more source