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Mexiletine in Plasma by High Pressure Liquid Chromatography

Therapeutic Drug Monitoring, 1981
We report here a novel high pressure liquid chromatographic (HPLC) technique for use in therapeutic monitoring of the primary amine antiarrhythmic drug mexiletine in plasma samples. Mexiletine and its structural analogue, the internal standard Ko 768, are extracted with heptane after alkalinization of the sample. The extracts are evaporated to dryness,
R, Kelly   +4 more
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High-pressure liquid chromatography of steroidal alkaloids

Journal of Chromatography A, 1976
High-pressure liquid chromatography was used to separate the following steroidal alkaloids: tomatidine, solanidine, solasodine, rubijervine, veratramine and jervine. The method was used to prepare crystalline solanidine from a crude mixture of aglycones obtained from Solanum chacoense, and to separate radioactive solanidine from extracts of potato ...
I R, Hunter   +3 more
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Forensic aspects of high-pressure liquid chromatography

Journal of Chromatography A, 1976
This paper reviews the applications of high-pressure liquid chromatography (HPLC) to forensic problems, and discusses some of the developments that have taken place in the use of the technique in the Metropolitan Police Laboratory. Preparation of octadecyltrichlorosilane-modified silica is described and some of the chromatographic characteristics of ...
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Determination of Thiopental by High Pressure Liquid Chromatography

Acta Pharmacologica et Toxicologica, 1979
AbstractA specific and rapid reverse phase HPLC‐method for the determination of thiopental in serum and in protein free solutions is described. No extraction is used. The detection limit is about 0.090 μg/ml for serum and about 0.030 μg/ml for buffer solutions. The retention time is 3.80 min.
J H, Christensen, F, Andreasen
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A fluorescence detector for high-pressure liquid chromatography

Journal of Chromatography A, 1977
We describe a fluorescence spectrophotometer adapted with a micro quartz flow cell to record the output of modern liquid chromatographs. The optical system is double beam in that the light source variations are cancelled out by a second photomultiplier, thus enhancing the sensitivity of the technique. The emission spectra may be scanned by stopping the
W, Slavin, A T, Williams, R F, Adams
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Separation of cytokinins by High Pressure Liquid Chromatography

Planta, 1975
A number of cytokinin reference compounds have been successfully separated by High Pressure Liquid Chromatography using columns of pellicular strong cation exchange resin and of pellicular polyamide. On polyamide, all cytokinins were eluted within 10 min with an aqueous buffer but on the cation exchange resin some cytokinins (generally those with bulky
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High-pressure liquid chromatography of androgens

Journal of Chromatography A, 1979
I R, Hunter, M K, Walden, E, Heftmann
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Liquid-liquid partition coefficients by high-pressure liquid chromatography

Journal of Medicinal Chemistry, 1975
Lipid-water partition values can be rapidly and reliably measured by high-pressure liquid chromatography (HPLC) on bonded octadecylsialne supports. This method has been developed and applied to a family of hypotensive triaminopyrimidine 3-oxides. The measured column retention values for this class of compounds correlate well with the values calculated ...
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High-pressure liquid chromatography of corticosteroids

Journal of Chromatography A, 1973
J C, Touchstone, W, Wortmann
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