Results 221 to 230 of about 1,253,208 (321)

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, EarlyView.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source

Cyclosporin G analysis and monitoring by high pressure liquid chromatography [PDF]

, 1986
Burckart, GJ, Ptachcinski, RJ, Starzl, TE, Todo, S, Venkataramanan, R, Zaghloul, I   +5 more
core  

Accelerated vaccine process development by orthogonal protein characterization. [PDF]

Sci Rep
James DA, Szymkowicz L, Yin L, Shah H, Leach M, Chicz RM.   +5 more
europepmc   +1 more source

Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

Advanced Science, EarlyView.
Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen, Zongwei Li, Zhihong Fang, Zou Li, Daoyan Yang, Yuan Li, Shurong Liu, Zhiqiang Liu, Rui Liu, Huan Liu   +9 more
wiley   +1 more source

Metabolic Signatures in Adipose Tissue Linking Lipophilic Persistent Organic Pollutant Mixtures to Blood Pressure Five Years After Bariatric Surgery Among Adolescents. [PDF]

Environ Sci Technol
Pan S, Li Z, Walker DI, Baumert BO, Wang H, Goodrich JA, Rock S, Inge TH, Jenkins TM, Sisley S, Bartell SM, Xanthakos S, Lin X, McNeil B, Robuck AR, Mullins CE, La Merill MA, Garcia E, Aung MT, Eckel SP, McConnell R, Conti DV, Ryder JR, Chatzi L.   +23 more
europepmc   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

Biopharmaceutical Analysis by HPLC: Practices and Challenges. [PDF]

Chonnam Med J
Mahdi G, Alamdary A, Kaghazian H, Ahmadi N, Mardani R, Gholami A.   +5 more
europepmc   +1 more source

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation

Advanced Science, EarlyView.
Humanized corneal stroma‐like adhesive patches (HCSPs) are developed for lamellar keratoplasty and corneal perforation repair. HCSPs exhibit histological, optical, and biomechanical characteristics similar to those of the natural cornea, with improved wet tissue adhesion, anti‐degradation, and anti‐swelling capabilities compared to conventional tissue ...
Long Zhao, Zhen Shi, Xiaoyu Zhang, Jingting Wang, Shang Yang, Fuyan Wang, Tan Li, Qingjun Zhou, Ting Wang, Weiyun Shi   +9 more
wiley   +1 more source

Microplate Reader-TLC-HPLC-UPLC-MS: A Rapid Screening Strategy for Isoliquiritigenin-Transforming Bacteria. [PDF]

Sensors (Basel)
Nie C, Liu R, Yang S, Li P, Zhang J.
europepmc   +1 more source

Affinity‐Based Isolation and One‐Pot Analysis of Extracellular Vesicles from Biofluids Using Phase Separated Zwitterionic Coacervates

Advanced Science, EarlyView.
This study presents a novel method for affinity‐based isolation and analysis of extracellular vesicles from biofluids using phase‐separated zwitterionic coacervates functionalized with a membrane‐sensing peptide. This technology minimizes nonspecific binding, enabling high‐yield isolation and direct one‐pot biomarker profiling.
Francesca Torrini, Roberto Frigerio, Jonathan Garlipp, Philippe Lenzen, Karl Normak, Carolina Paganini, Marina Cretich, Alessandro Gori, Paolo Arosio   +8 more
wiley   +1 more source