Results 191 to 200 of about 370,485 (298)

A Cobotic, Digitally Controlled Schlenk‐line Unlocks Access to Elusive Lewis‐Base Stabilised Copper Bis(Disilylamides)

open access: yesAngewandte Chemie International Edition, EarlyView.
A Cobotic digital chemistry approach succeeds where manual synthesis failed. Herein, we present our new “AutoSchlenk” line which, coupled with other digital chemistry tools, was key to the synthesis and isolation of an unstable, and previously inaccessible, three‐coordinate Cu(II) hexamethylsilylamide complex. Abstract Silylamides are important ligands
Nicola L. Bell   +5 more
wiley   +1 more source

Machine learning‐augmented molecular dynamics simulations (MD) reveal insights into the disconnect between affinity and activation of ZTP riboswitch ligands

open access: yesAngewandte Chemie International Edition, Accepted Article.
The challenge of targeting RNA with small molecules necessitates a better understanding of RNA‐ligand interaction mechanisms. However, the dynamic nature of nucleic acids, their ligand‐induced stabilization, and how conformational changes influence gene expression pose significant difficulties for experimental investigation.
Christopher Fullenkamp   +8 more
wiley   +1 more source

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

open access: yesAngewandte Chemie International Edition, Accepted Article.
Pseudouridine‐5’‐triphosphate (ΨTP) and the N1‐methylated derivative (m1ΨTP) are critical monomer building blocks of the currently used mRNA vaccines, yet efficient methods of their synthesis from readily accessible substrates remain underdeveloped. We herein report notably atom‐economic and high‐yielding biocatalytic route toward ΨTP (83% yield) and ...
Martin Pfeiffer   +4 more
wiley   +1 more source

Integrating Affinity Chromatography in the Platform Process for Adenovirus Purification. [PDF]

open access: yesBiotechnol Bioeng
Wu Y   +7 more
europepmc   +1 more source

“Dead Lithium” Formation and Mitigation Strategies in Anode‐Free Li‐Metal Batteries

open access: yesBatteries &Supercaps, Volume 8, Issue 3, March 2025.
Anode‐free lithium metal batteries, though promising due to their high energy density, face challenges from dead lithium formation. “Dead lithium”, disconnected from the anode, causes capacity loss, increased resistance, and safety risks. This review explores the origins of dead lithium, its impact on battery performance, and potential strategies for ...
Mozaffar Abdollahifar, Andrea Paolella
wiley   +1 more source

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