Results 241 to 250 of about 558,654 (343)

Building Molecules by a Self‐Replicator That Catalyzes Acyl Hydrazone Formation

Angewandte Chemie, EarlyView.
A self‐replicator efficiently catalyzes the formation of acyl hydrazone bonds between a set of different substrates. In addition to previously reported (bond‐breaking) catalytic activity, this renders the self‐replicator highly promiscuous, which is a good starting point for Darwinian experiments en route to de‐novo life.
Kayleigh S. van Esterik, Tommaso Marchetti, Sijbren Otto   +2 more
wiley   +2 more sources

Optimization of thrombopoietin mimetic peptide fusion proteins with albumin-binding domain for enhanced bioactivity and extended half-life. [PDF]

Sci Rep
Ying J, Zheng Y, Xu X, Yang J, Hu A, Gao G.   +5 more
europepmc   +1 more source

Assessing Angiogenic Properties In Vitro or In Ovo of Pre‐Crosslinked Alginate‐Dialdehyde‐Gelatin Hydrogels Incorporating Boron‐Doped Mesoporous Bioactive Glass Particles

Advanced NanoBiomed Research, EarlyView.
This study examines the influence of boron‐doped mesoporous bioactive glass nanoparticles (MBGN) blended in cast and 3D‐printed pre‐crosslinked alginate‐dialdehyde‐gelatin (ADA‐GEL). Addition of 0.5% and 1% MBGN did not negatively affect the viability of human umbilical vein endothelial cells (HUVECs), or the sprouting of HUVEC spheroids.
Rafael Schmid, Yvonne Kulicke, Evelin Sandor, Hsuan‐Heng Lu, Stefan Fleischer, Isabell Lang, Harald Wajant, Hana Kaňková, Andreas Arkudas, Annika Kengelbach‐Weigand, Raymund E. Horch, Aldo R. Boccaccini, Theresa Promny   +12 more
wiley   +1 more source

The use of multiple liquid chromatography methods augmented by phosphorus-31 nuclear magnetic resonance to characterize the diastereomer composition in synthetic oligonucleotides. [PDF]

J Chromatogr A
Ali M, Manghrani A, Szramowski M, Abdel-Megied AM, Liang L, Aberg NF, Yang K, Chen K, Wang Y, Zhang D, Fletcher S, Brinson RG, Jones JW.   +12 more
europepmc   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Extraction, purification, biological effects and applications of acrosin: a review. [PDF]

Front Cell Infect Microbiol
Quan R, Wu X, Zhang J, Liu R, Han J, Liu D.   +5 more
europepmc   +1 more source

Applications of Hydrophilic Interaction Chromatography in Pharmaceutical Impurity Profiling: A Comprehensive Review of Two Decades. [PDF]

Molecules
Ntorkou M, Zacharis CK.
europepmc   +1 more source

(Poly)Borylated Species as Modern Reactive Groups toward Unusual Synthetic Applications

Angewandte Chemie, EarlyView.
In this review, we spotlight recent breakthroughs in α‐polyboron‐substituted carbon‐centered intermediates (carbanion, carbocation, radical, and carbene) and polyborylated alkenes. By bridging fundamental reactivity with the application potential of these extraordinary species, we hope this review will serve as a roadmap for harnessing these unique ...
Nadim Eghbarieh, Nicole Hanania, Pinaki Nad, Tipu Alam, Tamir Kish, Ahmad Masarwa   +5 more
wiley   +1 more source

First Specific Analytical Method for Quantification of Halide Ions by UHPLC-MS Using Reverse Phase Chromatography C18. [PDF]

ACS Omega
Bonert S, Sayer H, Tabone G, Robert B.
europepmc   +1 more source

Selective Hydrodemethylation of Methylalkylbenzenes on Potassium Hydride

Angewandte Chemie, EarlyView.
Selective catalytic hydrodealkylation of methylalkylbenzenes on carbon‐supported potassium hydride is reported. The reaction exhibits a reactivity trend of 1° ∼ 2° ∼ 3° < CH3, which is opposite to traditional dealkylation and hydrodealkylation. DFT calculations on the (001) facet of KH with ortho‐ethyltoluene suggest that selectivity is controlled by ...
Puyang Tian, Marc Figueras‐Valls, Fei Chang, Francesc Viñes, Francesc Illas, Alexey Fedorov   +5 more
wiley   +1 more source