Drug Analytical Research, 2019 A stability-indicating micellar electrokinetic capillary chromatography (MEKC) method was developed and validated for the analysis of doxorubicin hydrochloride in injectable pharmaceutical dosage forms, using methotrexate as internal standard.
Daniele Rubert Nogueira-Librelotto +4 more
doaj +9 more sources
Química Nova, 2010 This work describes CE preconcentration strategies based on the effect of manipulation of the disperse/secondary velocity. Introduced by Terabe et al. in 1984, micellar electrokinetic chromatography is a powerful separation approach that increases the ...
Maria de Lourdes L. de Moraes +2 more
doaj +1 more source
SN Applied Sciences, 2021 This work presents an innovative silica-layer coated capillary with comparison study of the silica-layer coated capillary and the fused-silica capillary for the separation of seven phenolic acids viz.
Pattamaporn Hemwech +6 more
doaj +1 more source
A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development. [PDF]
ElectrophoresisABSTRACT The ICH Q14 guideline introduces a structured framework for analytical method development based on Analytical Quality by Design (AQbD) principles, aiming to ensure robust, reliable, and fit‐for‐purpose methods throughout the product lifecycle.
Tricht EV, Sänger-van de Griend CE.
europepmc +2 more sources
Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates [PDF]
, 2002 Antithrombin (AT) circulates in plasma in two isoforms, AT-alpha (90-95%) and AT-beta (5-10%). AT isoform proportions were measured in plasma samples of 17 healthy subjects and 26 posttraumatic or postoperative septic patients, as well as in 4 ...
Inthorn, D. +6 more
core +1 more source
20 Years of Fatty Acid Analysis by Capillary Electrophoresis
Molecules, 2014 A review taking into account the literature reports covering 20 years of fatty acid analysis by capillary electrophoresis is presented. This paper describes the evolution of fatty acid analysis using different CE modes such as capillary zone ...
Marcone Augusto Leal de Oliveira +6 more
doaj +1 more source
Development of a Micellar Electrokinetic Chromatographic Method with Indirect UV Detection for Pregabalin Determination in Serum Samples [PDF]
Pharmaceutical Sciences, 2018 Background: A micellar electrokinetic chromatographic (MEKC)/ indirect UV detection method with hydrodynamic and electrokinetic injection has been developed for the determination of pregabalin in the serum samples.
Hamid Reza Sargazi +3 more
doaj +1 more source
Method Development and Clinical Utility for Simultaneous Measurement of 21-Deoxycortisol, 17-Hydroxyprogesterone, Cortisol, and Cortisone Levels in Human Plasma Using UHPLC-MS/MS. [PDF]
Adv Pharmacol Pharm SciA simple and efficient validated assay for quantifying 21‐deoxycortisol (21‐DOC), 17‐hydroxyprogesterone (17‐OHP), cortisol, and cortisone in human plasma has been developed using ultra‐high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC‐MS/MS).
Alvi SN, Dgither SA, Al-Odaib A.
europepmc +2 more sources
Monitoring of cefepime in human serum and plasma by micellar electrokinetic capillary chromatography: Improvement of sample preparation and validation by liquid chromatography coupled to mass spectrometry. [PDF]
, 2017 Cefepime monitoring in deproteinized human serum and plasma by micellar electrokinetic capillary chromatography and liquid chromatography coupled to mass spectrometry in presence of other drugs is reported.
Šestáková, Nela +7 more
core +1 more source
The use of capillary electrophoresis in the simultaneous determination of fixed-dose combination drugs for cardiovascular diseases [PDF]
Trends in Pharmaceutical Sciences, 2020 Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and are usually multifactorial medical conditions. Usually cardiovascular patients must follow a complicated treatment scheme, containing several drugs.
Gabriel Hancu +3 more
doaj +1 more source