Results 221 to 230 of about 687,001 (274)

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Advances in Analytical Strategies to Study Cultural Heritage Samples-2nd Edition. [PDF]

Molecules
Astolfi ML, Sammartino MP.
europepmc   +1 more source

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Advanced Science, EarlyView.
Wall‐associated receptor‐like kinases (WAKLs) play pivotal roles in extracellular–intracellular signal transduction. Upon sensing Verticillium dahliae infestation at the plasma membrane, GbWAKL20 accumulates and transmits signals to the nucleus via endoplasmic reticulum‐mediated Golgi vesicle transport.
Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo   +7 more
wiley   +1 more source

Dried Matrix Spots for the Determination of Opiates and Opioids: Methodological Advances and Applications. [PDF]

Molecules
Rosendo LM, Gonçalves R, Martins R, Castro V, Rosado T, Barroso M, Gallardo E.   +6 more
europepmc   +1 more source

A Sustainable Adhesive Paradigm: Reversibly Reinforcing, Heat‐Free Bonding with Universal Substrates

Advanced Science, EarlyView.
A heat‐free adhesive system, delivering superior adhesion strength across metal, plastic, and glass substrates, is developed. Repeatable bonding with reinforcement instead of strength reduction enables error‐tolerant applications. This design paradigm establishes an eco‐friendly alternative to conventional adhesives, particularly suitable for ...
Shuang Zhang, Xin Jing, Shilong Wu, Fang Liu, Xiaoyuan Li, Yubin Huang   +5 more
wiley   +1 more source

Production system establishment and in vitro study of CD19/CD3ε bite antibody secreted from Pichia pastoris. [PDF]

Sci Rep
Kim B, Byun KT, Lee SH, Cheon SY, Kim CG.   +4 more
europepmc   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Ni-catalyzed enantioselective synthesis of β-aminoboronates via spin-center shift and proton transfer. [PDF]

Sci Adv
Wang Y, Wu G, Zhu W, Qi X, Song Q.
europepmc   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast. [PDF]

Sci Rep
Lewis RA, Hayles J, Hall MJ, Gray J, Mebrate S, Li J, Allenby NEE, Errington J.   +7 more
europepmc   +1 more source