Advanced Healthcare Materials, EarlyView.Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh +7 more
wiley +1 more source
Gallium/Indium-Promoted [4 + 2] Annulation of 2‑Aminobenzonitriles with Alkynes and Dimerization of 2‑Aminobenzonitriles: One-Pot Access to 4‑Aminoquinolines and 4‑Amino-2-Arylquinazolines. [PDF]
ACS OmegaSakai N +4 more
europepmc +1 more source
Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment
Advanced Healthcare Materials, EarlyView.EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim +5 more
wiley +1 more source
Hydroxy Group-Assisted Cu-Catalyzed Asymmetric Conjugate Addition for the Creation of an All-Carbon Quaternary Center. [PDF]
J Org ChemYamamoto T +4 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan +10 more
wiley +1 more source
Protocol for expressing and purifying recombinant full-length Tau by combining affinity chromatography with preparative HPLC. [PDF]
STAR ProtocJing R +4 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco +7 more
wiley +1 more source
A robust dilute-and-inject ion chromatography - Tandem mass spectrometry for urinary glyphosate quantification. [PDF]
MethodsXLouyer MV +3 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan +7 more
wiley +1 more source
Isolation of small extracellular vesicles from small volumes of blood plasma using size exclusion chromatography and density gradient ultracentrifugation. [PDF]
ElifeKong F +4 more
europepmc +1 more source