Results 51 to 60 of about 175,134 (306)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effects of Different Chromium Compounds on Hematology and Inflammatory Cytokines in Rats Fed High-Fat Diet

Frontiers in Immunology, 2021
The aim of the study was to determine how a high-fat diet supplemented with various forms of chromium affects hematological and immune parameters of the blood of rats. The rats received a standard diet or a high-fat diet supplemented with chromium at 0.3
Wojciech Dworzański, Iwona Sembratowicz, Ewelina Cholewińska, Krzysztof Tutaj, Bartosz Fotschki, Jerzy Juśkiewicz, Katarzyna Ognik   +6 more
doaj   +1 more source

Chromium removal from aqueous solution by a PEI-silica nanocomposite [PDF]

, 2018
It is essential and important to determine the adsorption mechanism as well as removal efficiency when using an adsorption technique to remove toxic heavy metals from wastewater.
A Maleki, A Mishra, AM Kłonkowski, AM Yusof, AP Wight, B Beverskog, B Song, B Song, BS Krishna, CAB Crisostomo, D Liu, D Mohan, D Perez-Quintanilla, E Lippincott, FM Rebelo, G Kresse, G Kresse, GH Kumar, H Ma, H Yoshitake, HJ Park, I Shimizu, J Drese, J Li, J Zhou, JG Yu, JP Perdew, JW Choi, K Momma, K Wang, KF Lam, KR Ko, LL Li, M Anbia, M Arkas, M Ghiaci, M Lu, M Shahid, M Yu, MK Dinker, MM Khader, MS Islam, N Cao, N Zaitseva, P Rekha, PE Blöchl, Q Cheng, S Golbaz, S Grimme, S Grimme, SA Khan, SW Choi, SX Liu, T Riaz, TZ Sadyrbaeva, W Liu, X Chen, XL Wang, Y Hideaki, Y Li, YJ Ko, Z Li, Z Xiao, ZR Yue, ZX Wu   +64 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

DEVELOPMENT OF RESOURCE-SAVING TECHNOLOGICAL SCHEME OF WASTEWATER TREATMENT ENGINEERING ENTERPRISES

Современная наука и инновации, 2022
Proved the feasibility of disposal of chromium ions (VI) "ballast" coolant components, is investigated and the optimal conditions of reduction reaction of chromium (VI) ions to chromium (III).
Elvira Pavlovna Doskina, Anastasia Vladimirovna Moskvicheva, Darya Olegovna Ignatkina, Pavel Alekseevich Sidyakin   +3 more
doaj  

Study of the dechroming of tanned leather wastes [PDF]

Hemijska Industrija, 2004
According to European legislation, it is not possible to dump any chromium-containing waste in Europe. The minimization of wastes is a key element in that strategy. It involves the application of clean technologies: low and non-waste technologies.
Botić Tatjana, Ilišković Nadežda V., Drljača Dijana   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analysis of Changes in the Microbial Biodiversity of Soil Contaminated with Cr(III) and Cr(VI)

Applied Sciences
Contamination with heavy metals, including chromium that exists in two oxidation states—Cr(III) and Cr(VI)—poses a significant challenge for the soil environment.
Edyta Boros-Lajszner, Jadwiga Wyszkowska, Małgorzata Baćmaga, Jan Kucharski   +3 more
doaj   +1 more source

The Effect of Vanadyl Sulphate and Chromium (III) Chloride Combination on Kidney Function of Diabetic Mice [PDF]

, 2014
The objective of this study was to identify the effect of two heavy metals, vanadyl sulphate and chromium (III) chloride on creatinine level of hyperglycemic mice induced by dexamethasone 11mg/kg.
Arifin, H. (Helmi), Dharma, S. (Surya), Dillasamola, D. (Dwisari)   +2 more
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