Results 201 to 210 of about 39,719 (247)
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Measurements of chromogranin B can serve as a complement to chromogranin A
Regulatory Peptides, 2007CgA has been shown to be an excellent marker for neuroendocrine tumours. However, there are two major drawbacks with CgA measurements; elevated levels are common in patients with decreased renal function and in patients on treatment with proton pump inhibitors. These problems are not seen with CgB measurements.
Mats, Stridsberg +4 more
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Chromogranin A and neuroendocrine tumors
Endocrinología y Nutrición (English Edition), 2013Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly ...
José Ángel, Díaz Pérez +1 more
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Endothelial Handling of Chromogranin A
2005The present study is the first to address the question of interaction between CGA and endothelial cells. It is evident that neither intact CGA nor N-terminal peptides activate endothelial cells by affecting the membrane potential. Nevertheless, bovine aorta endothelial cells (BAEC) bind and intemalise intact CGA in a temperature-dependent manner, and ...
MANDALA', Maurizio +3 more
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Chromogranin A and chromogranin B are sensitive circulating markers for phaeochromocytoma
European Journal of Endocrinology, 1997Abstract Specific assays for measurements of circulating chromogranin (Cg) A, CgB, CgC and pancreastatin (Ps) have recently been developed. The aim of the present study was to investigate the usefulness of these markers in diagnosing and following the effects of treatment of patients with phaeochromocytoma, and to compare the results with those
M, Stridsberg, E S, Husebye
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Chromogranin A and Chromogranin B in Noninvasive and Invasive Breast Carcinoma
Endocrine Pathology, 2002Recent progress in the study of chromogranins has revealed that there are many novel peptides derived from chromogranin with their multiple pathophysiologic roles. To learn the possible roles of chromogranin in breast carcinoma, we immunohistochemically investigated tissue localization of chromogranin A (CgA) and chromogranin B (CgB) in 10 normal ...
Noriko, Kimura +4 more
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NordiQC Assessments of Chromogranin A Immunoassays
Applied Immunohistochemistry & Molecular Morphology, 2019This paper is number 6 in a series developed through a partnership between ISIMM and Nordic IHC Quality Control with the purpose of reporting research assessing the performance characteristics of immunoassays in an external proficiency testing program.
Røge, Rasmus +4 more
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Chromogranin a as Biomarker in Diabetes
Biomarkers in Medicine, 2016Chromogranin A (CgA) is an established plasma marker of neuroendocrine tumors and has been suggested to also have a role as biomarker in other diseases. Whether CgA has any role as biomarker in diabetes is, however, unresolved, but its widespread distribution in the secretory granules in endocrine tissues including β cells and α cells in pancreas, and ...
Kasper, Broedbaek, Linda, Hilsted
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Chromogranin A: a multipurpose prohormone?
Acta Physiologica Scandinavica, 1994This minireview aims to discuss the new evidence for a multipurpose prohormone function for chromogranin A, the index member of the chromogranin/secretogranin family of universally distributed, uniquely acidic proteins.
K B, Helle, R H, Angeletti
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Human Pituitary Tumors Secrete Chromogranin-A*
The Journal of Clinical Endocrinology & Metabolism, 1989Chromogranin-A (CgA) has emerged as a serum and tissue marker for a number of endocrine tumors. We studied 15 patients with pituitary tumors to evaluate the clinical value of CgA as a serum and tissue marker for such tumors. One third of the patients had elevated serum CgA levels; 2 of these patients had nonsecreting pituitary tumors, and the other 3 ...
L J, Deftos +3 more
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Chromogranin A inhibits retinal dopamine release
Brain Research, 1993Chromogranin A (CGA), a peripherally active prohormone, is a soluble component in the secretory granules of many endocrine tissues and is cosecreted with their peptide or amine hormones. Using an antibody prepared against purified rat adrenal CGA, immunostaining was localized to the inner and outer plexiform layers of the rat retina and to selected ...
C J, Gibson, D G, Munoz
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