Results 161 to 170 of about 2,236 (206)

Chromogranin A

Current Opinion in Endocrinology, Diabetes & Obesity, 2016
The review summarizes the utility and limitations of chromogranin A (CgA) as a circulating biomarker for neuroendocrine tumors (NETs).Blood CgA measurement has numerous clinical limitations including poor assay reproducibility, low sensitivity (meta-analysis: 73%, 95% confidence interval: 0.71-0.76), and a paucity of prospective validation studies.
Mark, Kidd, Lisa, Bodei, Irvin M, Modlin
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Chromogranin A and chromogranin B are sensitive circulating markers for phaeochromocytoma

European Journal of Endocrinology, 1997
Abstract Specific assays for measurements of circulating chromogranin (Cg) A, CgB, CgC and pancreastatin (Ps) have recently been developed. The aim of the present study was to investigate the usefulness of these markers in diagnosing and following the effects of treatment of patients with phaeochromocytoma, and to compare the results with those
M, Stridsberg, E S, Husebye
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Chromogranin A and Chromogranin B in Noninvasive and Invasive Breast Carcinoma

Endocrine Pathology, 2002
Recent progress in the study of chromogranins has revealed that there are many novel peptides derived from chromogranin with their multiple pathophysiologic roles. To learn the possible roles of chromogranin in breast carcinoma, we immunohistochemically investigated tissue localization of chromogranin A (CgA) and chromogranin B (CgB) in 10 normal ...
Noriko, Kimura, Ryuichi, Yoshida, Shin-ichiro, Shiraishi, Monika, Pilichowska, Noriaki, Ohuchi   +4 more
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Proteolytic Processing of Chromogranins

2005
A number of peptides derived from the large chromogranin precursor proteins have been identified in neuroendocrine tissues and several of them have been attributed with functional data. In addition, various fragments were shown to be liberated by the action of prohormone convertases.
A, Laslop, A, Doblinger, U, Weiss
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Endothelial Handling of Chromogranin A

2005
The present study is the first to address the question of interaction between CGA and endothelial cells. It is evident that neither intact CGA nor N-terminal peptides activate endothelial cells by affecting the membrane potential. Nevertheless, bovine aorta endothelial cells (BAEC) bind and intemalise intact CGA in a temperature-dependent manner, and ...
MANDALA', Maurizio, STRIDSBERG M., HELLE K. B., SERCK HANSSEN G.   +3 more
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Measurements of chromogranin B can serve as a complement to chromogranin A

Regulatory Peptides, 2007
CgA has been shown to be an excellent marker for neuroendocrine tumours. However, there are two major drawbacks with CgA measurements; elevated levels are common in patients with decreased renal function and in patients on treatment with proton pump inhibitors. These problems are not seen with CgB measurements.
Mats, Stridsberg, Barbro, Eriksson, Bengt, Fellström, Gudjon, Kristiansson, Eva, Tiensuu Janson   +4 more
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Chromogranin peptides in brain diseases

Journal of Neural Transmission, 2011
Synaptic disturbances may play a key role in the pathophysiology of neuropsychiatric diseases. In this article, we review immunohistological findings of chromogranin peptides in neurodegenerative and neurodevelopmental disorders, with particular emphasis on Alzheimer's disease, the disorder chromogranins have been studied most extensively.
Michael, Willis, Irmgard, Leitner, Kurt A, Jellinger, Josef, Marksteiner   +3 more
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The granin-(chromogranin/secretogranin) family

Trends in Biochemical Sciences, 1991
The chromogranins/secretogranins, referred to in abbreviated form as granins, are a family of acidic secretory proteins that are found in the secretory granules of a wide variety of endocrine cells and neurons, being stored together with many different peptide hormones and neuropeptides.
W B, Huttner, H H, Gerdes, P, Rosa
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Chromogranin A and neuroendocrine tumors

Endocrinología y Nutrición (English Edition), 2013
Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Despite the limitations of testing methods, which require careful interpretation, especially in the case of gastrinomas, patients treated with somatostatin analogues, and poorly ...
José Ángel, Díaz Pérez, Maria, Currás Freixes   +1 more
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Chromogranin peptides in Alzheimer's disease

Experimental Gerontology, 2004
Synaptic disturbances may play a key role in the pathophysiology of Alzheimer's disease. To characterize differential synaptic alterations in the brains of Alzheimer patients, chromogranin A, chromogranin B and secretoneurin were applied as soluble constituents for large dense core vesicles, synaptophysin as a vesicle membrane marker and calbindin as a
Theresa, Lechner, Christine, Adlassnig, Christian, Humpel, Walter A, Kaufmann, Hans, Maier, Karin, Reinstadler-Kramer, Josef, Hinterhölzl, Sushil K, Mahata, Kurt A, Jellinger, Josef, Marksteiner   +9 more
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