Results 1 to 10 of about 103,006 (298)

GAL4-based functional screen of neuropeptides in Drosophila reproduction. [PDF]

PLoS ONE
Neuropeptides are evolutionarily conserved signaling molecules that regulate diverse behavioral and physiological processes, including reproduction.
Madhumala K Sadanandappa, Caliope Marin, Shinae Park, Shivaprasad H Sathyanarayana, Giovanni Bosco   +4 more
doaj   +2 more sources

Neuropeptidergic systems in psychiatric disorders [PDF]

Frontiers in Endocrinology
Neuropeptides represent a heterogeneous class of signalling molecules whose release has initially been described in the hypothalamus. Their release often follows a circadian rhythm and basal release may be enhanced by internal and external stressors ...
Sadat Hodzic, Therese Riedemann, Therese Riedemann   +2 more
doaj   +2 more sources

The Evolution and Diversity of SALMFamide Neuropeptides [PDF]

, 2013
The SALMFamides are a family of neuropeptides that act as muscle relaxants in echinoderms. Two types of SALMFamides have been identified: L-type (e.g.
Achhala, S, Elphick, MR, Martynyuk, N
core   +11 more sources

In Vitro Biological Evaluation of Aprepitant Based ¹⁷⁷Lu-Radioconjugates

Pharmaceutics, 2022
Currently, the search for promising NK1R-positive tumor-targeting radiopharmaceuticals based on the structure of small molecular antagonists of neurokinin-1 receptor can be observed.
Paweł K. Halik, Przemysław Koźmiński, Joanna Matalińska, Piotr F. J. Lipiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
doaj   +1 more source

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism

Frontiers in Pharmacology, 2021
Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the minute range, limiting its therapeutic use.
Adrien Flahault, Mathilde Keck, Pierre-Emmanuel Girault-Sotias, Lucie Esteoulle, Nadia De Mota, Dominique Bonnet, Catherine Llorens-Cortes   +6 more
doaj   +1 more source

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

Molecules, 2020
In the present contribution, we analyze the influence that C-terminal extension of short opioid peptide sequences by organic fragments has on receptor affinity, in vivo analgesic activity, and antimelanoma properties.
Jolanta Dyniewicz, Piotr F. J. Lipiński, Piotr Kosson, Marta Bochyńska-Czyż, Joanna Matalińska, Aleksandra Misicka   +5 more
doaj   +1 more source

Can keratin scaffolds be used for creating three-dimensional cell cultures?

Open Medicine, 2020
Three-dimensional (3D) cell cultures were created with the use of fur keratin associated proteins (F-KAPs) as scaffolds. The procedure of preparation F-KAP involves combinations of chemical activation and enzymatic digestion.
Bochynska-Czyz Marta, Redkiewicz Patrycja, Kozlowska Hanna, Matalinska Joanna, Konop Marek, Kosson Piotr   +5 more
doaj   +1 more source

Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors

Molecules, 2020
Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik, Piotr F. J. Lipiński, Joanna Matalińska, Przemysław Koźmiński, Aleksandra Misicka, Ewa Gniazdowska   +5 more
doaj   +1 more source

Neuropeptidomics: Mass Spectrometry-Based Identification and Quantitation of Neuropeptides [PDF]

Genomics & Informatics, 2016
Neuropeptides produced from prohormones by selective action of endopeptidases are vital signaling molecules, playing a critical role in a variety of physiological processes, such as addiction, depression, pain, and circadian rhythms.
Ji Eun Lee
doaj   +1 more source

CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti [PDF]

, 2020
Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs).
Ber, Lindsay Taylor, Lajevardi, Aryan, Matei, Andreea, Paluzzi, Jean-Paul, Paputsis, Christine, Sajadi, Farwa, Uyuklu, Ali, Wahedi, Azizia   +7 more
core   +1 more source