Results 31 to 40 of about 65,188 (311)

Migraine and neuropeptides [PDF]

Neuropeptides, 2015
Migraine is a common disabling neurovascular primary headache disorder. The pathomechanism is not clear, but extensive preclinical and clinical studies are ongoing. The structural basis of the leading hypothesis is the trigeminovascular system, which includes the trigeminal ganglion, the meningeal vasculature, and the distinct nuclei of the brainstem ...
Tajti János, Szok Délia, Majláth Zsófia, Tuka Bernadett, Csáti Anett, Vécsei László   +5 more
openaire   +3 more sources

Bioactivity and structural properties of chimeric analogs of the starfish SALMFamide neuropeptides S1 and S2

, 2014
The starfish SALMFamide neuropeptides S1 (GFNSALMFamide) and S2 (SGPYSFNSGLTFamide) are the prototypical members of a family of neuropeptides that act as muscle relaxants in echinoderms.
Jones, Christopher E. (R15179), Younan, ND, Viles, JH, Viles, John H., Younan, Nadine D., Jones, CE, Otara, CB, Elphick, MR, Elphick, Maurice R., Otara, Claire B.   +9 more
core   +1 more source

Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with SALMFamide neuropeptides

BMC Biology, 2022
Background Kisspeptins are neuropeptides that regulate reproductive maturation in mammals via G-protein-coupled receptor-mediated stimulation of gonadotropin-releasing hormone secretion from the hypothalamus.
Nayeli Escudero Castelán, Dean C. Semmens, Luis Alfonso Yañez Guerra, Meet Zandawala, Mario dos Reis, Susan E. Slade, James H. Scrivens, Cleidiane G. Zampronio, Alexandra M. Jones, Olivier Mirabeau, Maurice R. Elphick   +10 more
doaj   +1 more source

Neuropeptides in gut-brain axis and their influence on host immunity and stress

Computational and Structural Biotechnology Journal, 2020
In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous ...
Pingli Wei, Caitlin Keller, Lingjun Li
doaj   +1 more source

Structural analysis of the starfish SALMFamide neuropeptides S1 and S2: The N-terminal region of S2 facilitates self-association

, 2014
The neuropeptides S1 (GFNSALMFamide) and S2 (SGPYSFNSGLTFamide), which share sequence similarity, were discovered in the starfish Asterias rubens and are prototypical members of the SALMFamide family of neuropeptides in echinoderms.
Jones, Christopher E. (R15179), Younan, ND, Viles, JH, Viles, John H., Younan, Nadine D., Jones, CE, Otara, CB, Elphick, MR, Elphick, Maurice R., Otara, Claire B.   +9 more
core   +1 more source

Glucocorticoids are required for meal-induced changes in the expression of hypothalamic neuropeptides

, 2012
Glucocorticoid deficiency is associated with a decrease of food intake. Orexigenic peptides, neuropeptide Y (NPY) and agouti related protein (AgRP), and the anorexigenic peptide proopiomelanocortin (POMC), expressed in the arcuate nucleus of the ...
Uchoa, Ernane Torres, Antunes-Rodrigues, Jose, Elias, Lucila L. K., Silva, Lilian Eslaine C. M., de Castro, Margaret   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Peptidomimetic inhibitors of the VEGF-A165/NRP-1 complex obtained by modification of the C-terminal arginine

Amino Acids
Inhibitors of the interaction between Neuropilin-1 (NRP-1) and Vascular Endothelial Growth Factor-A165 (VEGF-A165) hold significant promise as therapeutic and diagnostic agents directed against cancers overexpressing NRP-1.
Dagmara Tymecka, Patrycja Redkiewicz, Piotr F. J. Lipiński, Aleksandra Misicka   +3 more
doaj   +1 more source

The Role of Neurokinin-1 Receptor in the Microenvironment of Inflammation and Cancer

The Scientific World Journal, 2012
The recent years have witnessed an exponential increase in cancer research, leading to a considerable investment in the field. However, with few exceptions, this effort has not yet translated into a better overall prognosis for patients with cancer, and ...
Marisa Rosso, Miguel Muñoz, Michael Berger   +2 more
doaj   +1 more source

Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal

, 2013
Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Nunez, Cristina, Edina Zelei, M Victoria Milanés, Polyák, Ágnes, Zelei, Edina, Agnes Polyák, Krisztina J Kovács, Kovács, Krisztina J., Cristina Núnez, Milanes, Victoria M., Pintér-Kübler, Bernadett, Ferenczi, Szilamér, Bernadett Pintér-Kübler, Szilamér Ferenczi   +13 more
core   +1 more source