Histopathology, EarlyView.FOXA1 is a highly sensitive diagnostic marker for prostate cancer. Besides prostatic adenocarcinoma, it is also expressed in 57%–80% of metastatic or primary prostatic small cell carcinomas, which lose traditional prostatic markers including NKX3.1. Although it is less specific than NKX3.1, it can serve as a valuable adjunct for confirming prostatic ...
Jianping Zhao +11 more
wiley +1 more source
Neuroimmune cross talk in the gut. Neuroendocrine and neuroimmune pathways contribute to the pathophysiology of irritable bowel syndrome [PDF]
, 2016 Irritable bowel syndrome (IBS) is a common disorder characterized by recurrent abdominal pain, bloating, and disturbed bowel habit, symptoms that impact the quality of life of sufferers.
O'Malley, Dervla
core +1 more source
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth +5 more
wiley +1 more source
Cromogranina A en adenomas hipofisarios humanos [PDF]
, 2018 Introducción: Las cromograninas son proteínas extensamente distribuidas en el sistema neuroendocrino, y su expresión puede usarse en la caracterización de los tumores neuroendocrinos.
Ferrer, Isidro (Ferrer Abizanda) +4 more
core
Angiogenic gene signature in human pancreatic cancer correlates with TGF-beta and inflammatory transcriptomes [PDF]
, 2015 Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, but overexpress pro-angiogenic factors and exhibit regions of microvasculature. Using RNA-seq data from The Cancer Genome Atlas (TCGA), we previously reported that ~12% of PDACs have an ...
Craven, Kelly E. +3 more
core +2 more sources
A 58‐year‐old woman experiencing occasional dizziness, impaired awareness, and deep feeling of fear
Brain Pathology, EarlyView.
Alessandro Selvaggini +5 more
wiley +1 more source
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation [PDF]
, 2015 The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes,
Davide eCittaro +8 more
core +2 more sources
Kinetics of neuroendocrine differentiation in an androgen-dependent human prostate xenograft model [PDF]
, 1999 It was previously shown in the PC-295 xenograft that the number of chromogranin A (CgA)-positive neuroendocrine (NE) cells increased after androgen withdrawal. NE cells did not proliferate and differentiated from G0-phase-arrested cells.
Jongsma, J. (Johan) +7 more
core +1 more source
Persistent Erythrocytosis in a Dog With a Spinal Sclerosing Paraganglioma
Veterinary Clinical Pathology, EarlyView.ABSTRACT A 7‐year‐old, male, castrated, mixed‐breed dog presented with right pelvic limb lameness and pain on posturing to defecate that began 1.5 years prior to presentation. Radiographs taken 8 months prior to presentation showed a small lytic lesion of the L6 vertebral body, and CBCs showed a persistently increased hematocrit (HCT) for at least 2 ...
Samuel V. Neal +11 more
wiley +1 more source
Identification and characterization of antibacterial compound(s) of cockroaches (Periplaneta americana) [PDF]
, 2017 Infectious diseases remain a significant threat to human health, contributing to more than 17 million deaths, annually. With the worsening trends of drug resistance, there is a need for newer and more powerful antimicrobial agents.
A Brüning +215 more
core +1 more source