Results 51 to 60 of about 6,064,178 (194)

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Towards sustainable multidisciplinary renal cancer tumour boards: redesigning the referral pathway

BJU International, EarlyView.
Objectives To develop and evaluate a complexity‐stratified referral pathway aimed at improving the sustainability, efficiency and resource utilisation of specialist multidisciplinary team (SMDT) meetings within a high‐volume tertiary renal cancer service.
Bhargab Ghoshal, Sarika Nalagatla, Max Roberts, Adam Mann, David Cullen, Victoria Horsfall, Andrea Da Silva, Abhishek Reekhaye, Prasad Patki, Ravi Barod, Faiz Mumtaz, Axel Bex   +11 more
wiley   +1 more source

The effect of time to nephrectomy on cancer‐specific mortality in pathological T stage (pT)1b–2 renal cancer

BJU International, EarlyView.
Objective To assess the impact of prolonged time to surgery on cancer‐specific mortality (CSM) in patients with pathological T stage (pT)1b–2 N0M0 renal cell carcinoma (RCC) treated with nephrectomy (either partial [PN] or radical [RN]). Within the Surveillance, Epidemiology and End Results (SEER) database (2004–2021), we tested the effect of time to ...
Michele Nicolazzini, Federico Polverino, Leonardo Quarta, Maximilian Filzmayer, Michele Petix, Calogero Catanzaro, Nick Lee, Jordan A. Goyal, Nicola Longo, Gennaro Musi, Felix K. H. Chun, Alberto Briganti, Riccardo Schiavina, Shahrokh F. Shariat, Carlotta Palumbo, Alessandro Volpe, Fred Saad, Pierre I. Karakiewicz   +17 more
wiley   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

Chromophobe cell renal carcinoma: a case report [PDF]

, 2000
Chromophobe cell renal carcinoma is an uncommon subtype of renal cell carcinoma and the number of cases studied is still limited in Japan. We here report a case of chromophobe cell renal carcinoma in a 41-year-old Mexican male.
相原, 衣江, 鈴木, 孝治, 佐藤, 宏和, 宮澤, 克人, 池田, 龍介, 川村, 研二   +5 more
core  

Apoptosis in Chromophobe Renal Cell Carcinoma and Renal Oncocytoma

Acta clinica Croatica, 2010
Introduction Renal oncocytoma is a benign epithelial tumor, composed of oncocytes, large eosinophilic cells. It represents 3-9% of renal tumors. Chromophobe renal cell carcinoma (ChRCC) is a distinct subtype of renal cell carcinoma and comprises approximately 5% of all renal tumors. Two main variants are classic and eosinophilic ChRCC.
Cesarec, Sanja, Demirović, Alma, Čupić, Hrvoje, Krušlin, Božo, Belicza, Mladen   +4 more
openaire   +4 more sources

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Chromophobe Renal Cell Carcinoma with Osteosarcoma Differentiation: Case Report and Literature Review

, 2010
Chromophobe renal cell carcinoma is a distinct subtype of renal cell carcinoma that is well known for its relatively good prognosis. When it presents with sarcomatoid differentiation, necrosis of the sarcomatoid area or angiolymphatic invasion, it ...
Jong-Shiaw Jin, Tai-Lung Cha, Yao-Feng Li, Cheng-Ping Yu   +3 more
core   +1 more source

HierAnom‐Path: Zero‐Shot Rare Cancer Detection in Histopathology via Hierarchical Foundation Model Adaptation

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Rare cancers collectively represent 20%–25% of all malignancies yet yield fewer than 50 annotated whole‐slide images (WSIs) per subtype in publicly available archives, rendering supervised deep learning inapplicable. We present HierAnom‐Path, to the best of our knowledge, the first framework for zero‐shot rare cancer anomaly detection in ...
Noora Saleem Jumaah, Mohanad Sameer Jabbar, Saif H. Alwaeli, Noor Ayesha, Mohamed Babiker A. Mohamed, Muhammad I. Khan   +5 more
wiley   +1 more source

The Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation

Electronic Journal of General Medicine, 2014
We present a rare case of a 52-year-old woman with a chromofobe renal cell carcinoma that had sarcomatoid components. The tumor, 70x60mm in size, was incidentally found by abdominal ultrasonography. An abdominal computed tomography demonstrated a well-demarcated solid tumor arising from the upper pole of the right kidney.
RESİM, Sefa, BAKARİS, Sevgi, CİTİL, Rana, BENLİOGLU, Can, EFE, Erkan   +4 more
openaire   +2 more sources