Results 91 to 100 of about 1,274,518 (371)

Study on Types of Chromosomal Abnormalities among Children and Adolescents in Hamadan

open access: yesپژوهان, 2021
Aims: Problems caused by chromosomal abnormalities along with long-term disabilities can have devastating effects on the patient, family, health care system and society.
Fatemeh Bahreini   +2 more
doaj  

Chromosomal Structural Abnormality Diagnosis by Homologous Similarity [PDF]

open access: yes
Pathogenic chromosome abnormalities are very common among the general population. While numerical chromosome abnormalities can be quickly and precisely detected, structural chromosome abnormalities are far more complex and typically require considerable efforts by human experts for identification.
arxiv   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

open access: yesMolecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock   +10 more
wiley   +1 more source

Discovery of Phylogenetic Relevant Y-chromosome Variants in 1000 Genomes Project Data [PDF]

open access: yesarXiv, 2013
Current Y chromosome research is limited in the poor resolution of Y chromosome phylogenetic tree. Entirely sequenced Y chromosomes in numerous human individuals have only recently become available by the advent of next-generation sequencing technology. The 1000 Genomes Project has sequenced Y chromosomes from more than 1000 males.
arxiv  

Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

open access: yesEMBO Journal, 1998
Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways, homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 participates in the first recombinational repair pathway while Ku proteins are involved in NHEJ ...
M. Takata   +8 more
semanticscholar   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

open access: yesMolecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar   +4 more
wiley   +1 more source

Reactions of Triticum urartu accessions to two races of the wheat yellow rust pathogen

open access: yesCrop Journal, 2018
Triticum urartu (AA, 2n = 2x = 14), a wild grass endemic to the Fertile Crescent (FC), is the progenitor of the A subgenome in common wheat. It belongs to the primary gene pool for wheat improvement. Here, we evaluated the yellow rust (caused by Puccinia
Jibin Xiao   +9 more
doaj  

Studying Abnormal Chromosomal Diseases Using Patient-Derived Induced Pluripotent Stem Cells

open access: yesFrontiers in Cellular Neuroscience, 2020
Chromosomal abnormality causes congenital and acquired intractable diseases. In general, there are no fundamental treatments for these diseases. To establish platforms to develop therapeutics for these diseases, patient-derived induced pluripotent stem ...
Yohei Hayashi   +2 more
doaj   +1 more source

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2007
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics.
R. Beroukhim   +30 more
semanticscholar   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti   +8 more
wiley   +1 more source

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