Results 81 to 90 of about 575,297 (315)

Geographical structure of the Y-chromosomal genetic landscape of the Levant: a coastal-inland contrast

, 2009
We have examined the male-specific phylogeography of the Levant and its surroundings by analyzing Y-chromosomal haplogroup distributions using 5874 samples (885 new) from 23 countries.
Tyler-Smith, C., Xue, Yali, Harmanani, Haidar, Izaabel, Hassan, El-Sibai, M., Ashrafian Bonab, Maziar, Hashwa, F., Platt, Daniel E., Youhanna, Sonia C., Haber, Marc; id_orcid, Harmanani, H., Zalloua, P., Haber, Marc, Behbehani, J., Bonab, Maziar Ashrafian, Haber, M., Sanyoura, May F., Platt, D., Zalloua, Pierre A., Tyler-Smith, Chris, The Genographic Consortium, Izaabel, H., El-Sibai, Mirvat, Behbehani, Jaafar, Youhanna, S., Sanyoura, M., Hashwa, Fuad, Wells, R., Wells, R. Spencer, Xue, Y.   +29 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Natural System of Chromosome Transfer in Yersinia pseudotuberculosis [PDF]

, 2012
The High Pathogenicity Island of Yersinia pseudotuberculosis IP32637 was previously shown to be horizontally transferable as part of a large chromosomal segment.
Biliana Lesic, Didier Mazel (158958), Magaly Ducos-Galand, Didier Mazel, Magaly Ducos-Galand (178854), Marie-Christine Prévost, Prévost Marie-Christine, Huon Christèle, Marie-Laure Rosso, Ducos-Galand, Magaly, Zouine, Mohamed, Marie-Christine Prévost (2280838), Christèle Huon (178859), Marie-Laure Rosso (178864), Carniel Elisabeth, Christèle Huon, Elisabeth Carniel (87260), Ducos-Galand Magaly, Mohamed Zouine, Mazel, Didier, Biliana Lesic (45391), Elisabeth Carniel, Lesic, Biliana, Rosso, Marie-Laure, Mazel Didier, Prévost, Marie-Christine, Mohamed Zouine (178847), Zouine Mohamed, Lesic Biliana, Huon, Christèle, Carniel, Elisabeth, Rosso Marie-Laure   +31 more
core   +1 more source

Chromosomal instability of purebred and crossbred dairy cows

, 2022
The article presents the results of research on the karyotype characteristics variability in purebred and crossbred dairy cows. The material for the research was peripheral blood samples of purebred firstborn cows of the Ukrainian red-spotted dairy and ...
V. Dzitsiuk, L. Starodub, T. Dyman
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

B Chromosomes – A Matter of Chromosome Drive [PDF]

Frontiers in Plant Science, 2017
B chromosomes are supernumerary chromosomes which are often preferentially inherited, deviating from usual Mendelian segregation. The balance between the so-called chromosome drive and the negative effects that the presence of Bs applies on the fitness of their host determines the frequency of Bs in a particular population.
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Chromosomal changes and recent diversification in the Andean genus Jaborosa (Solanaceae) [PDF]

, 2016
With the purpose of discussing the evolutionary dynamics of the karyotypes and their relationship with key geological events, CMA/DAPI banding and FISH techniques were applied to metaphase chromosomes of 13 Jaborosa species plus Sclerophylax spinescens ...
Marcela Moré, Barboza, Gloria Estela, Moreno, Natalia Cecilia, Gloria Barboza, More, Marcela, Chiarini, Franco Ezequiel, Franco Chiarini, Natalia Moreno   +7 more
core   +1 more source

Pattern of Chromosomal Aberrations in Patients from North East Iran [PDF]

Cell Journal, 2013
Objective: Chromosomal aberrations are common causes of multiple anomaly syndromes. Recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques ...
Saeedeh Ghazaey, Farzaneh Mirzaei, Mitra Ahadian, Fatemeh Keifi, Semiramis Tootian, Mohammad Reza Abbaszadegan   +5 more
doaj  

Study on Types of Chromosomal Abnormalities among Children and Adolescents in Hamadan

پژوهان, 2021
Aims: Problems caused by chromosomal abnormalities along with long-term disabilities can have devastating effects on the patient, family, health care system and society.
Fatemeh Bahreini, Negar Shamloei, Razieh Amini   +2 more
doaj