Results 1 to 10 of about 1,002,198 (296)
Epilepsy, EEG and chromosomal rearrangements [PDF]
Epilepsia OpenChromosomal abnormalities are associated with a broad spectrum of clinical manifestations, one of the more commonly observed of which is epilepsy.
Justyna Paprocka +2 more
exaly +6 more sources
Chromoanagenesis: cataclysms behind complex chromosomal rearrangements
Molecular Cytogenetics, 2019 Background During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during ...
Franck Pellestor
doaj +3 more sources
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
Cell Stem Cell, 2021 Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases.
Giandomenico Turchiano +2 more
exaly +2 more sources
Genome Biology, 2017 Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly ...
Louise Harewood +7 more
doaj +2 more sources
Pharmaceutics, 2021 Methotrexate (MTX)-mediated gene amplification has been widely used in Chinese hamster ovary (CHO) cells for the biomanufacturing of therapeutic proteins.
Jong Youn Baik +2 more
exaly +3 more sources
Chromosomal rearrangements as a source of new gene formation in Drosophila yakuba. [PDF]
PLoS Genetics, 2019 The origins of new genes are among the most fundamental questions in evolutionary biology. Our understanding of the ways that new genetic material appears and how that genetic material shapes population variation remains incomplete.
Nicholas B Stewart, Rebekah L Rogers
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Molecular Cell, 2018 Chromosomal rearrangements including large DNA-fragment inversions, deletions, and duplications by Cas9 with paired sgRNAs are important to investigate genome structural variations and developmental gene regulation, but little is known about the ...
Jinhuan Li, Yingbin Liu, Qiang Wu
exaly +2 more sources
The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements
Biomolecules, 2021 Incorrect reparation of DNA double-strand breaks (DSB) leading to chromosomal rearrangements is one of oncogenesis’s primary causes. Recently published data elucidate the key role of various types of RNA in DSB formation, recognition and repair.
Denis Eriksonovich Demin
exaly +3 more sources
Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations. [PDF]
PLoS Genetics, 2013 Large-scale genome rearrangements have been observed in cells adapting to various selective conditions during laboratory evolution experiments. However, it remains unclear whether these types of mutations can be stably maintained in populations and how ...
Shang-Lin Chang +3 more
doaj +2 more sources
Frontiers in GeneticsIntroductionIndividuals with balanced chromosomal rearrangements are at an increased risk for infertility, recurrent miscarriages, and the birth of infants with congenital malformations.
Yanjun Tian
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