Results 11 to 20 of about 186,093 (250)
Pharmaceutics, 2021 Methotrexate (MTX)-mediated gene amplification has been widely used in Chinese hamster ovary (CHO) cells for the biomanufacturing of therapeutic proteins.
Jong Youn Baik +2 more
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Identification of a familial complex chromosomal rearrangement by optical genome mapping
Molecular Cytogenetics, 2022 Background Complex chromosomal rearrangements (CCRs) are rare chromosomal structural variations, containing a variety of rearrangements such as translocation, inversion and/or insertion.
Yang Yang, Wang Hao
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PLoS Genetics, 2021 Different species can find convergent solutions to adapt their genome to the same evolutionary constraints, although functional convergence promoted by chromosomal rearrangements in different species has not previously been found.
Laura G Macías +7 more
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Mechanisms of structural chromosomal rearrangement formation
Molecular Cytogenetics, 2022 Structural chromosomal rearrangements result from different mechanisms of formation, usually related to certain genomic architectural features that may lead to genetic instability.
Bruna Burssed +3 more
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A pipeline for complete characterization of complex germline rearrangements from long DNA reads
Genome Medicine, 2020 Background Many genetic/genomic disorders are caused by genomic rearrangements. Standard methods can often characterize these variations only partly, e.g., copy number changes or breakpoints.
Satomi Mitsuhashi +4 more
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Engineering chromosome rearrangements in cancer [PDF]
Disease Models & Mechanisms, 2021 ABSTRACT The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in ...
Salvador Alonso, Lukas E. Dow
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Insights into the origin of the high variability of multivalent-meiotic associations in holocentric chromosomes of Tityus (Archaeotityus) scorpions. [PDF]
PLoS ONE, 2018 Scorpions represent an intriguing group of animals characterized by a high incidence of heterozygous chromosomal rearrangements. In this work, we examined six species of Tityus (Archaeotityus) from Brazilian fauna with a particular focus on elucidating ...
Viviane Fagundes Mattos +3 more
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Gross Chromosomal Rearrangement at Centromeres
Biomolecules, 2023 Centromeres play essential roles in the faithful segregation of chromosomes. CENP-A, the centromere-specific histone H3 variant, and heterochromatin characterized by di- or tri-methylation of histone H3 9th lysine (H3K9) are the hallmarks of centromere chromatin.
Ran Xu, Ziyi Pan, Takuro Nakagawa
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BMC Microbiology, 2010 Background The chromosome of Streptomyces has been shown to be unstable, frequently undergoing gross chromosomal rearrangements. However, the mechanisms underlying this phenomenon remain unclear, with previous studies focused on two chromosomal ends as ...
Wen Ying +5 more
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Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]
, 2003 The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J. +7 more
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