Sequence features contributing to chromosomal rearrangements in Neisseria gonorrhoeae. [PDF]
PLoS ONE, 2012 Through whole genome sequence alignments, breakpoints in chromosomal synteny can be identified and the sequence features associated with these determined.
Russell Spencer-Smith +3 more
doaj +3 more sources
Investigating Potential Chromosomal Rearrangements during Laboratory Culture of Neisseria gonorrhoeae [PDF]
Microorganisms, 2018 Comparisons of genome sequence data between different strains and isolates of Neisseria spp., such as Neisseria gonorrhoeae, reveal that over the evolutionary history of these organisms, large scale chromosomal rearrangements have occurred.
Russell Spencer-Smith +3 more
doaj +3 more sources
Cytogenetic techniques in current biomedical research. Part II: chromosomal rearrangements [PDF]
Фундаментальная и клиническая медицина, 2022 Mutations represent a natural mechanism for adaptation of species to changing environmental conditions. Chromosomal rearrangements play a pivotal role in the evolution, as evidenced by the comparison of human and non-human primate karyotypes, and have ...
А. N. Volkov, O. I. Rytenkova
doaj +2 more sources
Chromoanagenesis: cataclysms behind complex chromosomal rearrangements [PDF]
Molecular Cytogenetics, 2019 Background During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during ...
Franck Pellestor
doaj +2 more sources
On the spot: very local chromosomal rearrangements [PDF]
F1000 Biology Reports, 2012 Over the last decade, the detection of chromosomal abnormalities has shifted from conventional karyotyping under a light microscope to molecular detection using microarrays. The latter technology identified copy number variation as a major source of variation in the human genome; moreover, copy number variants were found responsible for 10-20% of cases
Helsmoortel, Céline +2 more
openaire +5 more sources
Identification of a familial complex chromosomal rearrangement by optical genome mapping
Molecular Cytogenetics, 2022 Background Complex chromosomal rearrangements (CCRs) are rare chromosomal structural variations, containing a variety of rearrangements such as translocation, inversion and/or insertion.
Yang Yang, Wang Hao
doaj +1 more source
PLoS Genetics, 2021 Different species can find convergent solutions to adapt their genome to the same evolutionary constraints, although functional convergence promoted by chromosomal rearrangements in different species has not previously been found.
Laura G Macías +7 more
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Mechanisms of structural chromosomal rearrangement formation
Molecular Cytogenetics, 2022 Structural chromosomal rearrangements result from different mechanisms of formation, usually related to certain genomic architectural features that may lead to genetic instability.
Bruna Burssed +3 more
doaj +1 more source
Preimplantation genetic testing for complex chromosomal rearrangements: clinical outcomes and potential risk factors [PDF]
Frontiers in GeneticsLiu Fenghua
exaly +2 more sources
A pipeline for complete characterization of complex germline rearrangements from long DNA reads
Genome Medicine, 2020 Background Many genetic/genomic disorders are caused by genomic rearrangements. Standard methods can often characterize these variations only partly, e.g., copy number changes or breakpoints.
Satomi Mitsuhashi +4 more
doaj +1 more source