Results 41 to 50 of about 76,927 (296)
Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations. [PDF]
PLoS Genetics, 2013 Large-scale genome rearrangements have been observed in cells adapting to various selective conditions during laboratory evolution experiments. However, it remains unclear whether these types of mutations can be stably maintained in populations and how ...
Shang-Lin Chang +3 more
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Genome organization influences partner selection for chromosomal rearrangements [PDF]
, 2010 Chromosomal rearrangements occur as a consequence of the erroneous repair of DNA double-stranded breaks, and often underlie disease. The recurrent detection of specific tumorigenic rearrangements suggests that there is a mechanism behind chromosomal ...
Wijchers, P. J. +3 more
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Caryologia, 2021 Chromosomal rearrangements are an important process in the evolution of species. It is assumed that these rearrangements occur near repetitive sequences and heterochromatic regions.
Alice Lemos Costa +6 more
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DNA double-strand break repair pathways, chromosomal rearrangements and cancer. [PDF]
, 2011 Chromosomal rearrangements, which can lead to oncogene activation and tumour suppressor loss, are a hallmark of cancer cells. Such outcomes can result from both the repair and misrepair of DNA ends, which arise from a variety of lesions including DNA ...
Torben R. Kasparek +4 more
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Insects, 2011 Chromosomal rearrangements can alter the rate and patterns of gene flow within or between species through a reduction in the fitness of chromosomal hybrids or by reducing recombination rates in rearranged areas of the genome.
Steven J. B. Cooper +2 more
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Genome Biology, 2017 Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly ...
Louise Harewood +7 more
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Microorganisms, 2022 The Cre-loxP system produces structural variations, such as deletion, duplication, inversion and translocation, at specific loci and induces chromosomal rearrangements in the genome.
Haiyan Ren +6 more
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Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution [PDF]
, 2005 For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their DNA content rather than solely ...
Wienberg, Johannes, Wienberg, J.
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Stimulation of Chromosomal Rearrangements by Ribonucleotides [PDF]
Genetics, 2015 AbstractWe show by whole genome sequence analysis that loss of RNase H2 activity increases loss of heterozygosity (LOH) in Saccharomyces cerevisiae diploid strains harboring the pol2-M644G allele encoding a mutant version of DNA polymerase ε that increases ribonucleotide incorporation.
Hailey N, Conover +9 more
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Introducing defined chromosomal rearrangements into the mouse genome [PDF]
, 2001 Chromosomal rearrangements have been instrumental in genetic studies in Drosophila. Visibly marked deficiencies (deletions) are used in mapping studies and region-specific mutagenesis screens by providing segmental haploidy required to uncover recessive ...
Mills, A. A., Bradley, A., Zheng, B.
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