Results 51 to 60 of about 1,002,198 (296)

Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution [PDF]

, 2005
For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their DNA content rather than solely ...
Wienberg, Johannes, Wienberg, J.
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Stimulation of Chromosomal Rearrangements by Ribonucleotides [PDF]

Genetics, 2015
AbstractWe show by whole genome sequence analysis that loss of RNase H2 activity increases loss of heterozygosity (LOH) in Saccharomyces cerevisiae diploid strains harboring the pol2-M644G allele encoding a mutant version of DNA polymerase ε that increases ribonucleotide incorporation.
Hailey N, Conover, Scott A, Lujan, Mary J, Chapman, Deborah A, Cornelio, Rabab, Sharif, Jessica S, Williams, Alan B, Clark, Francheska, Camilo, Thomas A, Kunkel, Juan Lucas, Argueso   +9 more
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Whole-chromosome paints in maize reveal rearrangements, nuclear domains, and chromosomal relationships

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Whole-chromosome oligo-FISH paints using synthetic oligonucleotide libraries that can be amplified and labeled were generated for all 10 chromosomes of maize, facilitating chromosome studies with high sensitivity and specificity for ...
P. Albert, Zhang Tao, Kassandra Semrau, J. Rouillard, Yu-Hsin Kao, C. R. Wang, T. Danilova, Jiming Jiang, J. Birchler   +8 more
semanticscholar   +1 more source

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. [PDF]

, 2010
BACKGROUND: The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa).
P T Scardino, Reid, A. H. M., D Brewer, Clark, J, S Edwards, H Møller, Kovacs, G., Gerald, W. L., Cuzick, J, Ambroisine, L., Cooper, C S, D M Berney, G Attard, de Bono, J S, J Cuzick, Cuzick, J., Reid, A H M, C S Cooper, Foster, C. S., Fletcher, A., Scardino, P. T., Fisher, G, Møller, H, Brewer, D, G Fisher, C S Foster, A Fletcher, Scardino, P T, Flohr, P., Scardino, PT, J S de Bono, de Bono, J. S., V E Reuter, Reuter, V. E., Cooper, CS, Edwards, S., de Bono, JS, G Kovacs, J Clark, Brewer, D., Attard, G, Fletcher, A, P Flohr, Flohr, P, Berney, D. M., Moller, H.; id_orcid, A H M Reid, Attard, G., Kovacs, G, Berney, DM, Edwards, S, L Ambroisine, Fisher, G., Foster, C S, Reuter, V E, Clark, J., Gerald, WL, Transatlantic Prostate Group, W L Gerald, Ambroisine, L, Reid, AHM, Foster, CS, Reuter, VE, Cooper, C. S., Gerald, W L, Berney, D M   +65 more
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Chromosomal rearrangements.

, 2013
Percentage of cells displaying chromosomal rearrangements including dicentric chromosome formation (A) and complex rearrangements (B). The effects were investigated in SCC61, SQ20B, and DMF/BSO (TTT)-treated SQ20B cell lines after 10 Gy of X-ray or 5 Gy ...
Thierry Douki (298019), Claire Rodriguez-Lafrasse (298022), Maïté Hanot (298006), Nicolas Foray (298017), Michaël Beuve (298012), Anthony Colliaux (298015), Anthony Boivin (298008), Céline Malésys (298010), Dominique Ardail (298021)   +8 more
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Chromosomal rearrangements in chondromatous tumors [PDF]

Cancer, 1990
Short-term cultures from 16 chondromatous tumors, 15 primary and one recurrent, were analyzed cytogenetically. Clonal chromosome aberrations were found in one of six benign tumors and in seven of ten malignant tumors. A chondroma had a complex translocation involving chromosomes X, 8, 12, and 13, as well as a deletion of the derivative chromosome 8. In
N, Mandahl, S, Heim, K, Arheden, A, Rydholm, H, Willén, F, Mitelman   +5 more
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Multi-invasions Are Recombination Byproducts That Induce Chromosomal Rearrangements

Cell, 2017
SUMMARY Inaccurate repair of broken chromosomes generates structural variants that can fuel evolution and inflict pathology. We describe a novel rearrangement mechanism in which translocation between intact chromosomes is induced by a lesion on a third ...
Aurèle Piazza, W. D. Wright, W. Heyer
semanticscholar   +1 more source

Prenatal origin of childhood AML occurs less frequently than in childhood ALL [PDF]

, 2006
Background While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive.
Meyer, Claus, Schneider, Bjoern, Votava, Felix, Madzo Jozef, Claus Meyer, Jan Trka, Zuna, Jan, Meyer Claus, Marschalek Rolf, Schneider Bjoern, Votava Felix, Tatiana Burjanivova, Burjanivova Tatiana, Zuna Jan, Katerina Muzikova, Muzikova, Katerina, Jan Zuna, Madzo, Jozef, Muzikova Katerina, Burjanivova, Tatiana, Stary Jan, Tatiana Burjanivova, Trka Jan, Marschalek, Rolf (Prof. Dr.), Bjoern Schneider, Rolf Marschalek, Jozef Madzo, Jan Stary, Felix Votava, Trka, Jan, Rolf Marschalek, Stary, Jan   +31 more
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Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization [PDF]

, 1990
Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes
Cremer, Thomas, Emmerich, Patricia, Cremer, Christoph, Lichter, Peter, Popp, Susanne   +4 more
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Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

, 2011
: BACKGROUND: Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently ...
Cuppen, E., Marlous Hoogstraat, Lieshout, S., van, Stef van Lieshout, Ivo Renkens, van Lieshout, S., Roosmalen van, M., Belt van de, J., Marco Koudijs, Hoogstraat, M., Voest, E.E., Koudijs, M.J., Isaac J Nijman, Edwin Cuppen, van Roosmalen, M., Ruben van 't Slot, José van de Belt, Masoumeh Tavakoli-Yaraki, Wijnand Roessingh, Vermaat, J.S., Slot, R., van 't, Nijman, I.J., Kloosterman, W.P., Lieshout van, S., Emile Voest, Renkens, I., Oscar Paling, Joost S Vermaat, Vermaat, J.E., Wigard P Kloosterman, Van't Slot, R., Belt, J., van de, van de Belt, J., Roessingh, W., Paling, O., Slot Van't, R., Guryev, V., Roosmalen, M.J., van, Tavakoli-Yaraki, M., Victor Guryev, Markus J van Roosmalen   +40 more
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