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On the spot: very local chromosomal rearrangements [PDF]
F1000 Biology Reports, 2012 Over the last decade, the detection of chromosomal abnormalities has shifted from conventional karyotyping under a light microscope to molecular detection using microarrays. The latter technology identified copy number variation as a major source of variation in the human genome; moreover, copy number variants were found responsible for 10-20% of cases
Helsmoortel, Céline +2 more
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How does DNA break during chromosomal translocations?
, 2011 Chromosomal translocations are one of the most common types of genetic rearrangements and are molecular signatures for many types of cancers. They are considered as primary causes for cancers, especially lymphoma and leukemia.
M. Nambiar +3 more
core +1 more source
, 2023 Frequency of chromosomal rearrangements in larvae of Simulium mellah from Spain, Almería province, Tabernas, El Cautivo.
Francisco Collantes (548345) +5 more
core +1 more source
High-Definition Cytogenetic Mapping of modern sugarcane cultivars by Oligo-FISH
Industrial Crops and ProductsSugarcane (Saccharum spp.), a dual-purpose crop valued for sugar and energy production, serves as an important industrial raw material and has substantial economic impact.
Qilong Ling +7 more
doaj +1 more source
Bezmiâlem Science, 2022 Objective:Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. For diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential ...
Bengisu GÖKKAYA +7 more
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Introducing defined chromosomal rearrangements into the mouse genome
, 2001 Chromosomal rearrangements have been instrumental in genetic studies in Drosophila. Visibly marked deficiencies (deletions) are used in mapping studies and region-specific mutagenesis screens by providing segmental haploidy required to uncover recessive ...
Mills, A. A., Bradley, A., Zheng, B.
core +1 more source
, 2016 Summary of diagnostic chromosomal rearrangements for cytoforms of the Simulium tuberosum group in Vietnam.
Van Lun Low (488512) +7 more
core +1 more source
Tracing cancer evolution and heterogeneity using Hi-C
Nature Communications, 2023 Chromosomal rearrangements can initiate and drive cancer progression, yet it has been challenging to evaluate their impact, especially in genetically heterogeneous solid cancers.
Dan Daniel Erdmann-Pham +10 more
doaj +1 more source
[Chromosome rearrangements in leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology, 1991 Information on the presence of specific chromosomal structural abnormalities in certain tumors has been increasing. Although the tumor specific chromosomal abnormalities were deemed important, it was not until the chromosomal location of several oncogenes was determined that the real molecular significance became apparent.
openaire +2 more sources
Genome BiologyChromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang +6 more
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