Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
eLife, 2019 Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years.
Maja Kneissig +13 more
doaj +1 more source
Chromosomal control of pig populations in France: 2002-2006 survey [PDF]
, 2007 The chromosomal control of pig populations has been widely developed in France over the last ten years. By December 31st, 2006, 13 765 individuals had been karyotyped in our laboratory, 62% of these since 2002.
BERLAND, H.M. +21 more
core +2 more sources
Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution [PDF]
, 2010 Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying these types of structural genomic variation are not fully understood.
Skinner, Benjamin M. +6 more
core +1 more source
Chromosomal rearrangements formed by rrn recombination do not improve replichore balance in host-specific Salmonella enterica serovars. [PDF]
PLoS ONE, 2010 Most of the ∼2,600 serovars of Salmonella enterica have a broad host range as well as a conserved gene order. In contrast, some Salmonella serovars are host-specific and frequently exhibit large chromosomal rearrangements from recombination between rrn ...
T David Matthews +2 more
doaj +1 more source
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer [PDF]
, 2011 : BACKGROUND: Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was recently ...
Cuppen, E. +40 more
core +3 more sources
Chromosome Rearrangements in Canine Fibrosarcomas [PDF]
Journal of Heredity, 2005 We have previously reported the use of six- and seven-color paint sets in the analysis of canine soft tissue sarcomas. Here we combine this technique with flow sorting of translocation chromosomes, reverse painting, and polymerase chain reaction (PCR) analysis of the gene content of the reverse paint in order to provide a more detailed analysis of ...
D R, Sargan +6 more
openaire +2 more sources
Karyotypic Evolution of the Common and Silverleaf Sunflower Genomes
The Plant Genome, 2009 Silverleaf sunflower ( Torrey and Gray) has been an important source of favorable alleles for broadening genetic diversity and enhancing agriculturally important traits in common sunflower ( L.), and, as the closest living relative of , provides an ...
Adam F. Heesacker +5 more
doaj +1 more source
The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary [PDF]
, 1994 Fluorescencein situ hybridization (FISH) of microlibraries established from distinct chromosome subregions can test the evolutionary conservation of chromosome bands as well as chromosomal rearrangements that occurred during primate evolution and will ...
Cremer, Thomas +8 more
core +1 more source
Frontiers in Genetics, 2023 Chromosome rearrangement is one of the main causes of abortion. In individuals with double chromosomal rearrangements, the abortion rate and the risk of producing abnormal chromosomal embryos are increased.
Jun Ren +32 more
doaj +1 more source
Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]
, 2000 At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J. +11 more
core +1 more source