Results 21 to 30 of about 1,114,920 (242)
Molecular Ecology, 2020 Gene flow has tremendous importance for local adaptation, by influencing the fate of de novo mutations, maintaining standing genetic variation and driving adaptive introgression.
H. Cayuela +14 more
semanticscholar +1 more source
A pipeline for complete characterization of complex germline rearrangements from long DNA reads
Genome Medicine, 2020 Background Many genetic/genomic disorders are caused by genomic rearrangements. Standard methods can often characterize these variations only partly, e.g., copy number changes or breakpoints.
Satomi Mitsuhashi +4 more
doaj +1 more source
Insights into the origin of the high variability of multivalent-meiotic associations in holocentric chromosomes of Tityus (Archaeotityus) scorpions. [PDF]
PLoS ONE, 2018 Scorpions represent an intriguing group of animals characterized by a high incidence of heterozygous chromosomal rearrangements. In this work, we examined six species of Tityus (Archaeotityus) from Brazilian fauna with a particular focus on elucidating ...
Viviane Fagundes Mattos +3 more
doaj +1 more source
Genes, 2020 Reptiles are notable for the extensive genomic diversity and species richness among amniote classes, but there is nevertheless a need for detailed genome-scale studies. Although the monophyletic amniotes have recently been a focus of attention through an
S. F. Ahmad +4 more
semanticscholar +1 more source
BMC Microbiology, 2010 Background The chromosome of Streptomyces has been shown to be unstable, frequently undergoing gross chromosomal rearrangements. However, the mechanisms underlying this phenomenon remain unclear, with previous studies focused on two chromosomal ends as ...
Wen Ying +5 more
doaj +1 more source
Chromosomal rearrangements and their neoantigenic potential in mesothelioma
Translational Lung Cancer Research, 2020 Chromosomal rearrangements are a defining molecular feature of mesothelioma that are not readily detected by standard DNA sequencing approaches but could be detected by whole genome sequencing methods such as mate-pair sequencing.
A. Mansfield, T. Peikert, G. Vasmatzis
semanticscholar +1 more source
Micronuclei-based model system reveals functional consequences of chromothripsis in human cells
eLife, 2019 Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years.
Maja Kneissig +13 more
doaj +1 more source
Engineering chromosome rearrangements in cancer [PDF]
Disease Models & Mechanisms, 2021 ABSTRACT The identification of large chromosomal rearrangements in cancers has multiplied exponentially over the last decade. These complex and often rare genomic events have traditionally been challenging to study, in part owing to lack of tools that efficiently engineer disease-associated inversions, deletions and translocations in ...
Salvador Alonso, Lukas E. Dow
openaire +3 more sources
Assessment of Molecular Cytogenetic Methods for the Detection of Chromosomal Abnormalities [PDF]
, 2006 Some marker chromosomes and chromosome rearrangements are difficult to identify using G-bands by Giemsa staining after trypsin treatment (G-banding) alone.
Maruyama, Hidehiko +5 more
core +1 more source
Chromosomal rearrangements formed by rrn recombination do not improve replichore balance in host-specific Salmonella enterica serovars. [PDF]
PLoS ONE, 2010 Most of the ∼2,600 serovars of Salmonella enterica have a broad host range as well as a conserved gene order. In contrast, some Salmonella serovars are host-specific and frequently exhibit large chromosomal rearrangements from recombination between rrn ...
T David Matthews +2 more
doaj +1 more source