Results 61 to 70 of about 638,215 (311)

Tracking chromosomal origins in the Northern Italy system of metacentric races of the house mouse

, 2022
The Western European house mouse is chromosomally diverse, with diploid karyotypes ranging from the standard 40 telocentric chromosomes down to 22 chromosomes.
Gabriel, Sofia I, Searle, Jeremy B, Searle, Jeremy Byron, Hauffe, Heidi C., Hughes, Jonathan J, Gabriel, Sofia I., Panithanarak, Thadsin, Giménez, Mabel Dionisia, Giménez, Mabel D, Scascitelli, Moira, Förster, Daniel W, Hughes, Jonathan J., Förster, Daniel W.   +12 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Chromosomal disorders - Karyotype indications [PDF]

, 2003
Educational Items on Chromosomal disorders - Karyotype ...
Huret, JL, L Dallaire, Dallaire, L, JL Huret   +3 more
core   +1 more source

A Chromosome RNAissance [PDF]

Cell, 2002
In RNA-mediated interference (RNAi), double-stranded RNAs (dsRNAs) target complementary mRNAs for degradation. New work demonstrates that essential chromosomal functions are mediated through RNAi protein components and short RNAs, which alter chromosome function at specific DNA loci via histone modification.
Dernburg, Abby F., Karpen, Gary H.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution [PDF]

, 2010
Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying these types of structural genomic variation are not fully understood.
Skinner, Benjamin M., Bunzey, Sydney K., Ellegren, Hans, Völker, Martin, Backström, Niclas, Langley, Elizabeth J, Griffin, Darren K., Skinner, Benjamin M, Bunzey, Sydney K, Griffin, Darren K, Ellegren, Hans,, Backström, Niclas,   +11 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1 [PDF]

, 2010
The histone methyltransferase SU(VAR)3-9 plays an important role in the formation of heterochromatin within the eukaryotic nucleus. Several studies have shown that the formation of condensed chromatin is highly regulated during development, suggesting ...
Johansen Kristen M., Boeke, Joern, Regnard Catherine, Peter B Becker, Kristen M Johansen, Weili Cai, Becker Peter B., Boeke Joern, Johansen Jørgen, Imhof Axel, Regnard, Catherine, Cai, Weili, Johansen, Jørgen, Imhof, Axel, Becker, Peter B., Joern Boeke, Johansen, Kristen M, Catherine Regnard, Axel Imhof, Jørgen Johansen, Cai Weili   +20 more
core   +2 more sources

Chromosome cohesion: A polymerase for chromosome bridges [PDF]

Current Biology, 2000
How do cells ensure that sister chromatids produced during DNA replication stay connected with each other until their separation in anaphase? New insight is provided by the discovery of DNA polymerase kappa, which has been found to be required for building the connections between sister chromatids.
openaire   +2 more sources

Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania

Balkan Journal of Medical Genetics, 2015
The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital ...
Mierla Dana, Malageanu M., Tulin R., Albu D.   +3 more
doaj   +1 more source