Results 41 to 50 of about 575,297 (315)

Chromosomal instability in Streptomyces avermitilis: major deletion in the central region and stable circularized chromosome

BMC Microbiology, 2010
Background The chromosome of Streptomyces has been shown to be unstable, frequently undergoing gross chromosomal rearrangements. However, the mechanisms underlying this phenomenon remain unclear, with previous studies focused on two chromosomal ends as ...
Wen Ying, Chen Zhi, Zhang Xiaojuan, He Fei, Chen Wei, Li Jilun   +5 more
doaj   +1 more source

Clinical significance of chromosomal integrity in gastric cancers

The International Journal of Biological Markers, 2022
Background A whole-exome or targeted cancer genes panel by next-generation sequencing has been used widely in assisting individualized treatment decisions. Currently, multiple algorithms are developed to estimate DNA copy numbers based on sequencing data,
Rukui Zhang, Zhaorui Liu, Xusheng Chang, Yuan Gao, Huan Han, Xiaona Liu, Hui Cai, Qiqing Fu, Lei Liu, Kai Yin   +9 more
doaj   +1 more source

The genetic content of chromosomal inversions across a wide latitudinal gradient

, 2012
There is increasing evidence regarding the role of chromosomal inversions in relevant biological processes such as local adaptation and speciation. A classic example of the adaptive role of chromosomal polymorphisms is given by the clines of inversion ...
Simões, Pedro, Calabria Garcia, Gemma, Marta Pascual (88566), Balanyà Joan, Picão Osório, J., Balanyà i Maymó, Joan, Simões Pedro, João Picão-Osório, Pedro Simões (88565), Pascual Berniola, Marta, Gemma Calabria, Marta Pascual, Gemma Calabria (109704), Pascual Marta, João Picão-Osório (109707), Pedro Simões, Calabria Gemma, Picão-Osório João, Joan Balanyà, Joan Balanyà (109709)   +19 more
core   +1 more source

Chromosomal aberrations in transitional cell carcinoma that are predictive of disease outcome are independent of polyploidy [PDF]

, 1999
Objective To determine whether aneusomy for chromosomes 7, 9 and 17 (reported to predict recurrence in up to 65% of patients with superficial transitional cell bladder cancer and thus providing the opportunity for early and effective treatment) reflects ...
Watters, A.D., Going, J.J., Adie, L., Bartlett, J.M.S., Grigor, K.M.   +4 more
core   +1 more source

In silico characterization of chromosomally integrated blaCTX-M genes among clinical Enterobacteriaceae in Africa: insights from whole-genome analysis

Frontiers in Microbiology
Antimicrobial resistance (AMR) mediated by extended-spectrum β-lactamases (ESBLs) is a growing global concern, particularly among Enterobacteriaceae. The CTX-M-type ESBLs, encoded by the blaCTX-M gene, are of significant public health importance due to ...
Misheck Shawa, Misheck Shawa, Herman Chambaro, Harvey K. Kamboyi, Clement Sulwe, Joseph Y. Chizimu, Situmbeko J. Nasilele, Shohei Ogata, Shohei Ogata, Mulemba Samutela, Tuvshinzaya Zorigt, Steward Mudenda, Manyando Simbotwe, Mwamba Nsofwa, Jedidiah Chanda, Freeman Chabala, Mike Nundwe, Mike Nundwe, Joseph Ndebe, Msangwa Sinjani, Kyoko Hayashida, Kyoko Hayashida, Naganori Nao, Naganori Nao, Naganori Nao, Roma Chilengi, Hirofumi Sawa, Hirofumi Sawa, Hirofumi Sawa, Hirofumi Sawa, Hirofumi Sawa, Hirofumi Sawa, Hirofumi Sawa, Yasuhiko Suzuki, Yasuhiko Suzuki, Bernard Hang'ombe, Bernard Hang'ombe, Masahiro Kajihara, Masahiro Kajihara, Masahiro Kajihara, Hideaki Higashi, Hideaki Higashi   +41 more
doaj   +1 more source

A case–control study identifying the frequency and spectrum of chromosomal anomalies and variants in a cohort of 1000 couples with a known history of recurrent pregnancy loss in the Eastern region of India

Journal of Human Reproductive Sciences, 2021
Background: Recurrent pregnancy loss (RPL) is a common occurrence that affects up to 15% of couples in their reproductive years. In both males and females with RPL and infertility, chromosomal abnormalities play a significant impact.
Abhik Chakraborty, Sujata Kar, Purna Chandra Mohapatra, Birendranath Banerjee   +3 more
doaj   +1 more source

Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization [PDF]

, 1990
Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes
Cremer, Thomas, Emmerich, Patricia, Cremer, Christoph, Lichter, Peter, Popp, Susanne   +4 more
core   +1 more source

Could the mosaic pattern of chromosomal abnormality predict overall survival of patients with myelodysplastic syndrome?

Hematology/Oncology and Stem Cell Therapy, 2016
Objective/background: Myelodysplastic syndromes (MDSs) are a group of monoclonal hematopoietic diseases consisting of a number of various entities.
Mehmet Sevki Uyanik, Ahmet Muzaffer Demir, Idris Kurt, Muhammet Maden, Fulya Oz Puyan, Hakan Gurkan, Elif Gulsum Umit, Gulsum Emel Pamuk   +7 more
doaj   +1 more source

Cytogenetic findings in patients with intellectual disability and/or multiple congenital anomalies [PDF]

Journal of Analytical Research in Clinical Medicine, 2016
Introduction: Chromosomal abnormalities are a major etiology of intellectual disability (ID) and multiple congenital anomalies (MCAs). Screening for chromosomal aberrations by clinical diagnostic techniques has been primarily performed ...
Sima Derakhshan, Mahmoud Khaniani
doaj   +1 more source

Rare chromosomal abnormalities: Can they be identified using conventional first trimester combined screening methods?

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2021
Objective: To evaluate the performance of first trimester combined screening for the detection of rare chromosomal abnormalities, other than Trisomies 21, 18 or 13 or 45 × . Study design: A database containing 36,254 pregnancies was analyzed.
Daniel Kane, Mary E. D’Alton, Fergal D. Malone   +2 more
doaj   +1 more source