Results 291 to 300 of about 1,291,704 (346)

Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle

Advanced Science, EarlyView.
This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia, Fuwen Wang, Xiaoyu Luo, Shuang Li, Yang Lyu, Yining Zheng, Zhijie Ma, Kaixing Qu, Rende Song, Jianyong Liu, Jicai Zhang, Basang Wangdui, Basang Zhuzha, Suolang Quji, Li Zhao, Silang Wangmu, Ciren Luobu, Nima Cangjue, Danzeng Luosang, Suolang Sizhu, Haijian Cheng, Ruizhe Li, Zhipeng Wu, Ruihua Dang, Yongzhen Huang, Xianyong Lan, Luohao Xu, Haifei Hu, WaiYee Low, Zhuqing Zheng, Yu Wang, Yuanpeng Gao, Lu Deng, Johannes A. Lenstra, Jianlin Han, Xueyi Yang, Wenfa Lyu, Bizhi Huang, Chuzhao Lei, Ningbo Chen   +39 more
wiley   +1 more source

"End-to-End Chromosome Fusion" as the Main Driver of Descending Dysploidy in <i>Vigna lasiocarpa</i> (Mart. ex Benth.) Verdc. (Leguminosae Juss.). [PDF]

Plants (Basel)
Serafim L, Silva JH, Dias S, Oliveira ARDS, Nunes MC, da Costa AF, Benko-Iseppon AM, Jiang J, do Vale Martins L, Brasileiro-Vidal AC.   +9 more
europepmc   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Integrating genome and transcriptome analysis to decipher balanced structural variants in unsolved cases of neurodevelopmental disorders. [PDF]

Front Genet
Mellone S, Spano A, Vurchio D, Borgonovi G, Ugonotti A, Paglino G, Bianco A, Ronzani S, Sciancalepore M, Prodam F, Papa A, Viri M, Dianzani U, Giordano M.   +13 more
europepmc   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

Clinical analysis of karyotypes and phenotypes in 87 cases of Turner syndrome during transitional period. [PDF]

BMC Pediatr
Luo J, Yang L, Guo H, Yao H, Chen X, Feng L.   +5 more
europepmc   +1 more source

Genetic etiology of ventriculomegaly in 73 fetuses identified by High-Throughput sequencing. [PDF]

Sci Rep
Chenyue Z, Huiqin X, Jingbo G, Min G, Hao Y, Rong G, Guizhi C, Xiayu S, Jianrui W.   +8 more
europepmc   +1 more source

The application of irreversible genomic states to define and trace ancient cell type homologies. [PDF]

Evodevo
Simakov O, Wagner GP.
europepmc   +1 more source

Low-coverage whole-genome sequencing for differentiating cervical cancer from cervical intraepithelial neoplasia and benign diseases. [PDF]

Chromosome Res
Zhang T, Gu F, He JY, Li W, Han R, Liu X, Dai C, Qin Z, Zhang D, Lu J, Li H.   +10 more
europepmc   +1 more source