Results 291 to 300 of about 1,306,106 (344)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Clinical analysis of the effect of embryonic outcomes in carriers of chromosomal translocations from different parental sources: A retrospective cohort study of 178 couples. [PDF]

J Obstet Gynaecol Res
Guo Y, Liu X, Xie Z, Ma X.
europepmc   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Chromosomal Instability as a Driver of Therapeutic Resistance and Phenotypic Plasticity in Non-Small Cell Lung Cancer. [PDF]

J Cell Mol Med
Ma D, Wang J, Gao K.
europepmc   +1 more source

Synthetic data-driven AI approach for fetal chromosomal aneuploidies detection. [PDF]

Bioinform Adv
Hwang C, Adhikari KP, Oh G, Kim S.
europepmc   +1 more source

Performance and clinical implications of non-invasive prenatal testing for rare chromosomal abnormalities: a retrospective study of 94,125 cases. [PDF]

Front Mol Biosci
Qi H, Chen H, Zhang Z, Gan J, Liu H, Yuan X, Luo F, Chen J, Shen S.   +8 more
europepmc   +1 more source

Mutational Signatures in Radiation-Induced Cancer: A Review of Experimental Animal and Human Studies. [PDF]

Biology (Basel)
Daino K, Tsuruoka C, Ishikawa A, Kakinuma S, Imaoka T.   +4 more
europepmc   +1 more source

Case Report: Genomic insights and personalized treatment in dual primary esophageal squamous cell carcinoma and gastric adenocarcinoma. [PDF]

Front Oncol
Miao C, Guo Y, Yang H, Zhu S, Chen Y, Zhao W, Hu X.   +6 more
europepmc   +1 more source

Lithium chloride at environmental concentrations impairs microtubule function and promotes genotoxicity in Allium cepa. [PDF]

Sci Rep
Lima GG, Camilo-Cotrim CF, Silva JAP, Firmino MT, Silva NA, Aguiar ASN, Benvindo-Souza M, Borges LL, Caramori SS, Bailão EFLC, Almeida LM.   +10 more
europepmc   +1 more source