Results 201 to 210 of about 119,383 (327)

High Burden of Non-Clonal Chromosome Aberrations Before Onset of Detectable Neoplasia in Fanconi Anemia Bone Marrow

Sílvia Sánchez, Benilde García‐de Teresa, Marco A. Mejía-Barrera, Pedro A. Reyes, Antonio Paz-Martínez, Miguel A. Martínez, Moisés Ó. Fiesco-Roa, Angélica Monsiváis-Orozco, Bertha Molina, Leda Torres, Alfredo E. Rodríguez, Sara Frı́as   +11 more
openalex   +2 more sources

The Association between DNA Copy Number Aberrations at Chromosome 5q22 and Gastric Cancer

, 2014
Pei‐Chien Tsai, Szu‐Wei Huang, Hsiang-Lin Tsai, Cheng‐Jen Ma, Ming‐Feng Hou, I‐Ping Yang, Yung‐Song Wang, Suh‐Hang Hank Juo, Jaw‐Yuan Wang   +8 more
openalex   +2 more sources

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Light-controlled Spo11-less meiotic DNA breaks by MagTAQing lead to chromosomal aberrations. [PDF]

Nucleic Acids Res
Yone H, Kawashima Y, Hirai H, Oda AH, Sato M, Kono H, Ohta K.   +6 more
europepmc   +1 more source

Mitigative effect of caffeine against diclofenac-induced hepato-renal damage and chromosomal aberrations in male albino rats. [PDF]

BMC Complement Med Ther, 2022
Anwar MM, Laila IMI.
europepmc   +1 more source

Numerical chromosomal aberrations in Hodgkin's disease detected by in situ hybridisation on routine paraffin sections. [PDF]

, 1997
James H. Pringle, Jacqui Shaw, Angela Gillies, I Lauder   +3 more
openalex   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Impact of chromosomal aberrations detected by chromosome banding analysis in symptomatic Waldenström's macroglobulinemia. [PDF]

Ann Hematol
Ito K, Kitagawa T, Harada K, Hirano K, Sekiguchi N.   +4 more
europepmc   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Analysis of chromosomal aberrations in early pregnancy loss using high-throughput ligation-dependent probe amplification and single tandem repeats. [PDF]

Mol Cytogenet
Wei R, Hu H, Wang S, Tang J, Li J, Tong K, Wang C, Zhu J.   +7 more
europepmc   +1 more source