Results 191 to 200 of about 946,819 (342)

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Cytogenetic Profile of Chromosomal Aberrations in Leukemia Using the Fluorescence In Situ Hybridization (FISH) Method at a Tertiary Institution in Gauteng Province. [PDF]

Diagnostics (Basel)
Duma Z, Matsepane KC, Nkoana K, Pheeha SM, Mbele B, Simela-Tshabalala T, Tanyanyiwa DM.   +6 more
europepmc   +1 more source

Limited acquisition of chromosomal aberrations in human adult mesenchymal stromal cells.

Cell Stem Cell, 2012
L. Sensébé, K. Tarte, J. Galipeau, M. Krampera, I. Martin, D. Phinney, Yufang Shi   +6 more
semanticscholar   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

From Chromosomal Aberrations to Transcriptome Analysis: Four Decades of Research in Bivalve Genotoxicity. [PDF]

Int J Mol Sci
Khatir Z, Leitão A.
europepmc   +1 more source

Segmental chromosomal aberrations as the poor prognostic factor in children over 18 months with stage 3 neuroblastoma without MYCN amplification. [PDF]

Front Oncol, 2023
Wieczorek A, Szewczyk K, Klekawka T, Stefanowicz J, Ussowicz M, Drabik G, Pawinska-Wasikowska K, Balwierz W.   +7 more
europepmc   +1 more source

Analysis of chromosomes in molecular tumor and radiation cytogenetics: Approaches, apllications, perspectives [PDF]

, 1992
Cremer, Christoph, Cremer, Thomas
core  

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Chromosomal Aberrations in Fetuses With Isolated Persistent Right Umbilical Vein-A Nationwide Study. [PDF]

Prenat Diagn
Vedel C, Farlie R, Vase L, Nielsen LH, Jensen AN, Barken SS, Hjort-Pedersen K, Petersen OB.   +7 more
europepmc   +1 more source

Inside the chronic lymphocytic leukemia cell: miRNA and chromosomal aberrations. [PDF]

Mol Med Rep, 2022
Grenda A, Filip AA, Wąsik-Szczepanek E.
europepmc   +1 more source