Results 171 to 180 of about 946,819 (342)

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Proceedings of the National Academy of Sciences of the United States of America, 2007
R. Beroukhim, G. Getz, L. Nghiemphu, J. Barretina, Teli Hsueh, David Linhart, I. Vivanco, Jeffrey C. Lee, Julie Huang, Sethu Alexander, Jinyan Du, Tweeny R Kau, Roman K. Thomas, K. Shah, H. Soto, S. Perner, John R. Prensner, R. Debiasi, F. Demichelis, C. Hatton, M. Rubin, L. Garraway, S. Nelson, L. Liau, P. Mischel, T. Cloughesy, M. Meyerson, Todd Golub, E. Lander, I. Mellinghoff, W. Sellers   +30 more
semanticscholar   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Modification of cytogenetic and physiological effects of space flight factors by biologically active compounds [PDF]

Physiological and cytogenetic changes in the Welsh onion plants induced by a short (82 days) and long term (522 days) space flight are expressed in decrease of seed germination, inhibition of stem growth, depression of cell division in root meristem, and
Alekperov, U. K., Aliyev, A. A., Mashinskiy, A. L., Mekhti-Zade, E. R.   +3 more
core   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

STUDY OF GENOTOXICITY OF ENVIRONMENTAL CHEMICAL POLLUTION ON TWO SPECIES OF GENUS APODEMUS (RODENTIA MAMMALIA)

Iranian Journal of Public Health, 1998
In present work, genotoxicological effects of chemical pollution of an industrial region, on species of genus Apodemus (Rodentia, Mammalia), were studied. The two species were A.flavicolis and A.agrarius.
H. Pour-Jafari, D.D. Farhud, A.R. Mesdaghinia   +2 more
doaj  

Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series. [PDF]

BMC Endocr Disord, 2023
Elhadd T, Majzoub A, Wilson C, McCreight L, Mohamed MS, Green FC, Collier AJ.   +6 more
europepmc   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Genomic Proximity Mapping for Identification of Chromosomal Aberrations in Multiple Myeloma. [PDF]

Am J Hematol
Kandasamy RK, Hsu JS, Eacker S, Mangelson H, Stephens ZD, Dispenzieri A, Braggio E, Bergsagel PL, Fonseca R, Rajkumar SV, Kumar SK, Baughn LB, Gonsalves WI, Pandey A.   +13 more
europepmc   +1 more source

Optical Genome Mapping Helps to Identify BCR::JAK2 Rearrangement Arising from Cryptic Complex Chromosomal Aberrations: A Case Report and Literature Review. [PDF]

Genes (Basel), 2023
Vanjari N, Tang G, Toruner GA, Wang W, Thakral B, Zhao M, Dave BJ, Khoury JD, Medeiros LJ, Tang Z.   +9 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source