Results 151 to 160 of about 246,792 (294)

Application of non-invasive prenatal testing in screening chromosomal aberrations in pregnancies with different nuchal translucency cutoffs. [PDF]

Mol Cytogenet, 2023
Xu Y, Hu S, Chen L, Hao Y, Zhang H, Xu Z, Wu W, Deng L.   +7 more
europepmc   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Genomic Proximity Mapping for Identification of Chromosomal Aberrations in Multiple Myeloma. [PDF]

Am J Hematol
Kandasamy RK, Hsu JS, Eacker S, Mangelson H, Stephens ZD, Dispenzieri A, Braggio E, Bergsagel PL, Fonseca R, Rajkumar SV, Kumar SK, Baughn LB, Gonsalves WI, Pandey A.   +13 more
europepmc   +1 more source

Chromosomal Aberrations, Micronuclei, Blood Parameters and Received Doses in Workers Exposed to Ionizing Radiation. [PDF]

Med Lav, 2023
Djokovic J, Jankovic S, Milovanovic A, Bulat P.   +3 more
europepmc   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Studies of post-partum placentas provide insights into the origin of structural chromosomal aberrations. [PDF]

Hum Reprod
Thomsen SH, van Berkel A, van Veen S, van Koetsveld N, Joosten M, Diderich KEM, van den Born M, Srebniak MI, Van Opstal D.   +8 more
europepmc   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

Biological effects of ¹⁸F-FDG administration and CT dose during PET/CT: chromosomal aberrations in a two-center prospective observational study. [PDF]

Eur Radiol
Kawashima Y, Kinugasa Y, Ishibashi M, Fukumoto W, Miyata Y, Ideguchi R, Sakai C, Ishida M, Hirota S, Yoshinaga S, Nishibuchi I, Murakami Y, Loy-Caraos G, Bayasgalan N, Bayarjargal S, Shi L, Sun J, Horikoshi Y, Okada M, Nakamura Y, Awai K, Kudo T, Tashiro S.   +22 more
europepmc   +1 more source

Hypergonadotropic hypogonadism and chromosomal aberrations: clinical heterogeneity and implications on the health of elderly men, case series. [PDF]

BMC Endocr Disord, 2023
Elhadd T, Majzoub A, Wilson C, McCreight L, Mohamed MS, Green FC, Collier AJ.   +6 more
europepmc   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source