Results 211 to 220 of about 824,606 (327)

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Optical Genome Mapping for Comprehensive Assessment of Chromosomal Aberrations and Discovery of New Fusion Genes in Pediatric B-Acute Lymphoblastic Leukemia. [PDF]

Cancers (Basel), 2022
Gao H, Xu H, Wang C, Cui L, Huang X, Li W, Yue Z, Tian S, Zhao X, Xue T, Xing T, Li J, Wang Y, Zhang R, Li Z, Wang T.   +15 more
europepmc   +1 more source

EP09.49: Identifying right‐sided aortic arch is important step to identify associated congenital heart diseases and chromosomal aberrations [PDF]

V Kashyap, Nitin Kashyap, S K Verma, Vivek Kaushal, A.K. Kashyap   +4 more
openalex   +1 more source

Comparison of chromosomal aberrations frequency and polymorphism of GSTs genes in workers occupationally exposed to cytostatics or anaesthetics [PDF]

, 2009
Ľudovít Mušák, Erika Halášová, Tatiana Matáková, Lucia Letková, Ľudmila Vodičková, J Buchancová, Henrieta Hudečková, Oto Osina, Pavel Souček, Pavel Vodička   +9 more
openalex   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Contribution of chromosomal aberrations to the pathogenesis of primary and secondary amenorrhea: A study from Western Iran. [PDF]

Clin Exp Reprod Med
Azimi A, Heidari M, Alibakhshi R, Hamani S, Salimi N, Nejati P, Jalilian N.   +6 more
europepmc   +1 more source

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

Chromosomal aberrations and early mortality in a non-mammalian vertebrate: example from pressure-induced triploid Atlantic salmon. [PDF]

Heredity (Edinb)
Delaval A, Glover KA, Solberg MF, Fjelldal PG, Hansen T, Harvey AC.   +5 more
europepmc   +1 more source

Chromosomal Number Aberrations and Transformation in Adult Mouse Retinal Stem Cells In Vitro

, 2009
Meta W. Djojosubroto, F. Bollotte, Pratyaksha Wirapati, Freddy Radtke, Ivan Stamenkovic, Yvan Arsenijévic   +5 more
openalex   +2 more sources

Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98.

Journal of Clinical Oncology, 2010
C. von Neuhoff, D. Reinhardt, A. Sander, M. Zimmermann, J. Bradtke, D. Betts, Z. Zemanová, J. Starý, J. Bourquin, O. Haas, M. Dworzak, U. Creutzig   +11 more
semanticscholar   +1 more source