Results 241 to 250 of about 66,664 (302)
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On the formation of chromosomal aberrations
Mutation Research, 1970Abstract The exchange hypothesis and the breakage-first hypothesis are the 2 major hypotheses that describe how chromosomal aberrations might be produced. A critical test has shown that one important aspect of the exchange hypothesis is correct, namely that some aberrations that appear to be simple chromatid deletions are actually incomplete ...
J A, Heddle, D J, Bodycote
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The fate of chromosome aberrations
Journal of Theoretical Biology, 1973Abstract Chromosomal aberrations rapidly disappear from populations of dividing cells, but little is known about the details of the process. One may ask, for example, whether a cell with an acentric fragment is virtually certain to die after the first mitosis or whether it has a high probability of surviving to the second.
A V, Carrano, J A, Heddle
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Chromosome Aberrations and Cancer
Science, 1991Cancer may be defined as a progressive series of genetic events that occur in a single clone of cells because of alterations in a limited number of specific genes: the oncogenes and tumor suppressor genes. The association of consistent chromosome aberrations with particular types of cancer has led to the identification of some of these genes and the ...
E, Solomon, J, Borrow, A D, Goddard
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Chromosomal aberrations in man
The Journal of Pediatrics, 1961Summary The following are the most significant points to emerge in summarizing the present status of the field of human cytogenetics. 1. The human chromosome number is 46; a standard system of nomenclature has been established for identification of somatic metaphase chromosomes.
S, RAPPOPORT, W D, KAPLAN
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ULTRASOUND AND CHROMOSOME ABERRATIONS
Medical Journal of Australia, 1973Human and marsupial whole blood and blood-medium mixtures were irradiated with various doses of 2.25 MHz ultrasound and gamma rays. Doses of ultrasonic irradiation orders of magnitude higher than those used for diagnostic studies produced very few chromosome aberrations.
R D, Brock +4 more
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Heterochromatin and chromosome aberrations
Chromosoma, 1969The chromosome breaking effect of mitomycin C, methyl methanesulfonate, maleic hydrazide, 8-ethoxycaffeine and gamma rays on the primary root meristematic cells of Nigella damascena was studied. All the agents tested except 8-ethoxycaffeine, produced relatively fewer aberrations, when compared to Vicia faba cells, though both the species have nearly ...
A T, Natarajan, G, Ahnström
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Interpreting Chromosome Aberration Spectra
Journal of Computational Biology, 2007Ionizing radiation can damage cells by breaking both strands of DNA in multiple locations, essentially cutting chromosomes into pieces. The cell has enzymatic mechanisms to repair such breaks; however, these mechanisms are imperfect and, in an exchange process, may produce a large-scale rearrangement of the genome, called a chromosome aberration ...
Dan Levy +6 more
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Chromosomal aberrations in malnutrition
Metabolism, 1975The effects of feeding high (18%) and low (5%) protein diets on chromosomal aberrations in bone marrow cells of rats were investigated. Malnourished rats maintained on low protein diet had significantly higher incidence of breaks and deletions as compared to wellfed rats maintained on high protein diet. Well fed rats showed an increased aberration rate
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1999
Abstract In this chapter we consider gonadal maldevelopment caused by X-chromosome aberrations. As in Chapter 5, “gonadal maldevelopment” is defined broadly so that it includes defective spermatogenesis due to an extra X chromosome in XXY males and gonadal dysgenesis due to accelerated oocyte attrition in XO females. These two conditions,
Leonard Pinsky +2 more
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Abstract In this chapter we consider gonadal maldevelopment caused by X-chromosome aberrations. As in Chapter 5, “gonadal maldevelopment” is defined broadly so that it includes defective spermatogenesis due to an extra X chromosome in XXY males and gonadal dysgenesis due to accelerated oocyte attrition in XO females. These two conditions,
Leonard Pinsky +2 more
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Autosomal Chromosome Aberrations
1976Prior to the introduction of cytogenetic techniques in human medicine some 15 years ago, only a single chromosome aberration syndrome, Down’s syndrome, was known clinically, but its etiology was still unclear. By direct chromosome examination, it was later shown that the clinical picture of Down’s syndrome is caused by the presence of an additional No.
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