Results 261 to 270 of about 824,606 (327)

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine From Xylose in Escherichia Coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Use of chromosome aberrations for predicting genetic hazards to man

, 2011
J.G. Brewen
openalex   +1 more source

Additive and Partially Dominant Effects from Genomic Variation Contribute to Rice Heterosis

Advanced Science, EarlyView.
Additive and partially dominant effects, namely at mid‐parent levels or values between mid‐parent and parental levels, respectively, are the predominant inheritance patterns of heterosis‐associated molecules. These two genetic effects contribute to heterosis of agronomic traits in both rice and maize, as well as biomass heterosis in Arabidopsis ...
Zhiwu Dan, Yunping Chen, Wei Zhou, Yanghong Xu, Junran Huang, Yi Chen, Jizhou Meng, Guoxin Yao, Wenchao Huang   +8 more
wiley   +1 more source

Mepylome: A Point‐of‐Care Tumor Diagnostic Toolkit for Tumor DNA Methylation and Copy Number Analysis

Advanced Intelligent Systems, EarlyView.
DNA methylation and chromosomal copy number profiling have recently become essential for tumor diagnostics. The open‐source tool Mepylome enables this task in clinical routine. It combines several machine learning strategies and allows users to interactively examine respective data through an intuitive graphical interface. Running up to 65 times faster
Jon Brugger, Claus Hultschig, Daniel Baumhoer, Baptiste Ameline, Benjamin Maciej Freyter, Stephan Frank, Jürgen Hench   +6 more
wiley   +1 more source

Optisense: Computational Optimization for Strain Sensor Placement in Wearable Motion Tracking Systems

Advanced Intelligent Systems, EarlyView.
A computational framework for optimizing strain sensor placement in wearable motion tracking systems is presented. By combining dense strain mapping with a genetic algorithm, the method discovers counterintuitive yet highly effective configurations that reduce joint angle error by 32%.
Minu Kim, Juhyung Ahn, Jieun Seo, Steve Park, Joo Yong Sim   +4 more
wiley   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, EarlyView.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Growth Standards for Children With Smith–Magenis Syndrome (SMS)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS, OMIM 182290) is a complex syndromic diagnosis marked by neurobehavioral differences and distinct facial dysmorphisms, caused by haploinsufficiency of the retinoic acid‐1 (RAI1) gene either by a pathogenic sequence variant or deletion at chromosome 17p11.2 involving a portion or all of this gene.
Julie Hoover‐Fong, John McGready, Leah Fleming, Kerry Schulze, Folami Duncan, Alexis Leonard, Marie Christine de Blois Boucard, Danilo Moretti‐Ferreira, Andrea L. Gropman, Wendy J. Introne, Ann C. M. Smith   +10 more
wiley   +1 more source