Results 21 to 30 of about 824,606 (327)

Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells

Archives of Toxicology, 2018
Cannabidiol (CBD) and cannabidivarin (CBDV) are natural cannabinoids which are consumed in increasing amounts worldwide in cannabis extracts, as they prevent epilepsy, anxiety, and seizures.
C. Russo, F. Ferk, M. Mišík, Nathalie Ropek, A. Nersesyan, Doris Mejri, K. Holzmann, M. Lavorgna, M. Isidori, S. Knasmüller   +9 more
semanticscholar   +1 more source

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Nature Communications, 2021
Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks, mutations, and promote tumor development in mouse models of colorectal cancer (CRC).
A. Iftekhar, Hilmar Berger, Nassim Bouznad, Julian Heuberger, F. Boccellato, U. Dobrindt, H. Hermeking, Michael Sigal, T. Meyer   +8 more
semanticscholar   +1 more source

Origin and clinical relevance of chromosomal aberrations other than the common trisomies detected by genome-wide NIPS: results of the TRIDENT study

Genetics in Medicine, 2017
PurposeNoninvasive prenatal screening (NIPS) using cell-free DNA in maternal blood is highly sensitive for detecting fetal trisomies 21, 18, and 13. Using a genome-wide approach, other chromosome anomalies can also be detected.
D. Van Opstal, M. V. van Maarle, K. Lichtenbelt, M. Weiss, Heleen G Schuring-Blom, S. Bhola, M. Hoffer, Karin Huijsdens–van Amsterdam, M. Macville, A. Kooper, B. Faas, L. Govaerts, Gita Tan-Sindhunata, N. D. den Hollander, I. Feenstra, R. Galjaard, D. Oepkes, S. Ghesquiere, R. Brouwer, L. Beulen, Sander Bollen, M. Elferink, R. Straver, L. Henneman, G. Page-Christiaens, E. Sistermans   +25 more
semanticscholar   +1 more source

Risk of birth defects in children conceived by artificial oocyte activation and intracytoplasmic sperm injection: a meta-analysis

Reproductive Biology and Endocrinology, 2020
Background Whether artificial oocyte activation (ICSI-AOA) will increase the risk of birth defects remains controversial. Thus, we performed this study to evaluate the risk of birth defects and further compare the incidence of different birth defects ...
Rui Long, Meng Wang, Qi Yu Yang, Shi Qiao Hu, Li Xia Zhu, Lei Jin   +5 more
doaj   +1 more source

Techniques for detecting chromosomal aberrations in myelodysplastic syndromes

OncoTarget, 2017
Myelodysplastic syndromes (MDS) are a group of heterogeneous hematologic diseases. Chromosomal aberrations are important for the initiation, development, and progression of MDS.
Q. Song, M. Peng, Y. Chu, Shiang Huang
semanticscholar   +1 more source

The study of the impact of additional chromosomal aberrations and c-MYC and BCR::ABL1 genes amplification on CML patient’s characteristics: relation to haematological parameters and patient outcome

Egyptian Journal of Medical Human Genetics, 2023
Background Chronic myeloid leukaemia is characterised by genetic instability which results in additional cytogenetic aberrations that have been linked to progression to advanced phase.
Hend Attia, Dina Adel Fouad, Heba Samy
doaj   +1 more source

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

Nature Communications, 2016
Aneuploidy and copy-number alterations (CNAs) are a hallmark of human cancer. Although genetically engineered mouse models (GEMMs) are commonly used to model human cancer, their chromosomal landscapes remain underexplored.
U. Ben-David, G. Ha, Prasidda Khadka, Xin Jin, Bang Wong, L. Franke, T. Golub   +6 more
semanticscholar   +1 more source

Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. [PDF]

PLoS ONE, 2012
Chromosomal instability is the major form of genomic instability in cancer cells. Amongst various forms of chromosomal instability, pericentromeric or centromeric instability remains particularly poorly understood.
Wen Deng, Sai Wah Tsao, Xin-Yuan Guan, Annie L M Cheung   +3 more
doaj   +1 more source

Pattern of Chromosomal Aberrations in Patients from North East Iran [PDF]

Cell Journal, 2013
Objective: Chromosomal aberrations are common causes of multiple anomaly syndromes. Recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques ...
Saeedeh Ghazaey, Farzaneh Mirzaei, Mitra Ahadian, Fatemeh Keifi, Semiramis Tootian, Mohammad Reza Abbaszadegan   +5 more
doaj  

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: Structural chromosomal aberrations in blood lymphocytes represent a biomarker for cellular damage caused by genotoxic carcinogens and are an indicator of increased cancer risk.
Ludovit Musak, Zdenek Smerhovsky, Erika Halasova, Oto Osina, Lucia Letkova, Ludmila Vodickova, Veronika Polakova, Janka Buchancova, Kari Hemminki, Pavel Vodicka   +9 more
doaj   +1 more source