Results 201 to 210 of about 2,310,607 (369)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Chromosomal Abnormalities in Recurrent Pregnancy Loss at a Tertiary Care Center. [PDF]

Cureus
Sinha MB, Thakur P, Verma R.
europepmc   +1 more source

KLF1/EKLF expression in acute leukemia is correlated with chromosomal abnormalities

, 2020
Adnan Mansoor, Mohammad Omer Mansoor, Jay Patel, Shuchun Zhao, Yasodha Natkunam, James J. Bieker   +5 more
openalex   +2 more sources

Intraosseous intraneural perineurioma derived from the inferior alveolar nerve with an abnormality of chromosome 22 and expression of the BCR-ABL fusion gene: report of a case and review of recent literature [PDF]

, 2018
Jun Kurihara, Satoshi Yokoo, Miku Ichikawa, Takahiro Shimizu, Masaru Ogawa, Mai Seki   +5 more
openalex   +1 more source

Traditional karyotyping vs copy number variation sequencing for detection of chromosomal abnormalities associated with spontaneous miscarriage

Ultrasound in Obstetrics and Gynecology, 2015
S. Liu, L. Song, D. Cram, L. Xiong, K. Wang, R. Wu, J. Liu, K. Deng, B. Jia, Mei Zhong, F. Yang   +10 more
semanticscholar   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Chromosomal abnormalities of mesenchymal stromal cells in hematological malignancies. [PDF]

Oncogene
Lisboa MO, Borgonovo T, Fracaro L, Rangel Pozzo A, Brofman PRS, Mai S.   +5 more
europepmc   +1 more source

Structural abnormalities of autosomal chromosomes in the male partner do not influence fertilization and early development of embryos after intracytoplasmic sperm injection [PDF]

, 1997
Atsushi Yoshida, Y. Araki, Mitsuhiro Motoyama, S.-Y. Kim, Hyun Hwan Sung, Shigeo Araki, K Miura, Masafumi Shirai   +7 more
openalex   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, EarlyView.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

Resveratrol-Curcumin Hybrid Selectively Induces Chromosomal Abnormalities and Apoptosis in Colon Adenocarcinoma Cells. [PDF]

Antioxidants (Basel)
Baptistella MM, Siqueira AP, Magalhães DLS, Zavan B, de Oliveira CS, de Freitas Silva M, Falleiros Lima ET, Viegas C, Dala-Paula BM, Caixeta ES, Ionta M, de Oliveira PF.   +11 more
europepmc   +1 more source