Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. [PDF]
PLoS Genetics, 2013 During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Alice Copsey +13 more
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Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. [PDF]
PLoS Genetics, 2013 The number and distribution of crossover events are tightly regulated at prophase of meiosis I. The resolution of Holliday junctions by structure-specific endonucleases, including MUS-81, SLX-1, XPF-1 and GEN-1, is one of the main mechanisms proposed for
Takamune T Saito +4 more
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G3: Genes, Genomes, Genetics, 2017 Meiotic crossover frequencies show wide variation among organisms. But most organisms maintain at least one crossover per homolog pair (obligate crossover). In Saccharomyces cerevisiae, previous studies have shown crossover frequencies are reduced in the
Parijat Chakraborty +8 more
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Separable Crossover-Promoting and Crossover-Constraining Aspects of Zip1 Activity during Budding Yeast Meiosis. [PDF]
PLoS Genetics, 2015 Accurate chromosome segregation during meiosis relies on the presence of crossover events distributed among all chromosomes. MutSγ and MutLγ homologs (Msh4/5 and Mlh1/3) facilitate the formation of a prominent group of meiotic crossovers that mature ...
Karen Voelkel-Meiman +5 more
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The kinetochore prevents centromere-proximal crossover recombination during meiosis
eLife, 2015 During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased ...
Nadine Vincenten +9 more
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Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure [PDF]
Nucleic Acids Research, 2016 Rec8 is a prominent component of the meiotic prophase chromosome axis that mediates sister chromatid cohesion, homologous recombination and chromosome synapsis. Here, we explore the prophase roles of Rec8.
S. Tim Yoon +8 more
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Independent genetic basis of meiotic crossover positioning and interference in domestic pigs [PDF]
Scientific ReportsMeiotic crossover patterning shows huge variation within and between chromosomes, individuals, and species, yet the molecular and evolutionary causes and consequences of this variation remain poorly understood.
Cathrine Brekke +3 more
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The Density of Recombination-Associated Genomic Features Does Not Generally Explain the Broad-Scale Crossover Patterns in Chicken and Guinea Fowl [PDF]
AnimalsMeiotic recombination is essential for chromosomal segregation and facilitates the exchange between homologs, which leads to the transmission of new combinations of linked alleles to the progeny.
Luis F. Rossi, María Inés Pigozzi
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Excess crossovers impede faithful meiotic chromosome segregation in C. elegans.
PLoS Genetics, 2020 During meiosis, diploid organisms reduce their chromosome number by half to generate haploid gametes. This process depends on the repair of double strand DNA breaks as crossover recombination events between homologous chromosomes, which hold homologs ...
Jeremy A Hollis +6 more
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Optimizing chromosome dispersion quality: the key role of cell density [PDF]
Frontiers in Cell and Developmental BiologyObjectiveThis study aims to optimize metaphase dispersion in automated detection by quantitatively determining the optimal cell suspension density to enhance the accuracy and efficiency of chromosomal aberrations analysis.MethodsLymphocyte metaphase ...
Chao-Xian Gao +6 more
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