Excess crossovers impede faithful meiotic chromosome segregation in C. elegans.
PLoS Genetics, 2020 During meiosis, diploid organisms reduce their chromosome number by half to generate haploid gametes. This process depends on the repair of double strand DNA breaks as crossover recombination events between homologous chromosomes, which hold homologs ...
Jeremy A Hollis +6 more
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Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. [PDF]
PLoS Genetics, 2013 The number and distribution of crossover events are tightly regulated at prophase of meiosis I. The resolution of Holliday junctions by structure-specific endonucleases, including MUS-81, SLX-1, XPF-1 and GEN-1, is one of the main mechanisms proposed for
Takamune T Saito +4 more
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Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. [PDF]
PLoS Genetics, 2013 During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Alice Copsey +13 more
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Statistical analysis and simulations that account for simultaneous effects of positive, negative, and no crossover interference in multilocus recombination data [PDF]
BMC GenomicsCrossover interference (COI) is a widespread feature of homologous meiotic recombination. It can be quantified by the classical coefficient of coincidence (CoC), but this characteristic is highly variable and specific to the pair of chromosomal intervals
Shaul Sapielkin +3 more
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Redistribution of Meiotic Crossovers Along Wheat Chromosomes by Virus-Induced Gene Silencing [PDF]
Frontiers in Plant Science, 2021 Meiotic recombination is the main driver of genetic diversity in wheat breeding. The rate and location of crossover (CO) events are regulated by genetic and epigenetic factors.
Amir Raz +5 more
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Independent genetic basis of meiotic crossover positioning and interference in domestic pigs [PDF]
Scientific ReportsMeiotic crossover patterning shows huge variation within and between chromosomes, individuals, and species, yet the molecular and evolutionary causes and consequences of this variation remain poorly understood.
Cathrine Brekke +3 more
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The Density of Recombination-Associated Genomic Features Does Not Generally Explain the Broad-Scale Crossover Patterns in Chicken and Guinea Fowl [PDF]
AnimalsMeiotic recombination is essential for chromosomal segregation and facilitates the exchange between homologs, which leads to the transmission of new combinations of linked alleles to the progeny.
Luis F. Rossi, María Inés Pigozzi
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Sex-specific crossover distributions and variations in interference level along Arabidopsis thaliana chromosome 4. [PDF]
PLoS Genetics, 2007 In many species, sex-related differences in crossover (CO) rates have been described at chromosomal and regional levels. In this study, we determined the CO distribution along the entire Arabidopsis thaliana Chromosome 4 (18 Mb) in male and female ...
Jan Drouaud +8 more
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Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops [PDF]
eLife, 2017 Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
Jie Liu +8 more
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Optimizing chromosome dispersion quality: the key role of cell density [PDF]
Frontiers in Cell and Developmental BiologyObjectiveThis study aims to optimize metaphase dispersion in automated detection by quantitatively determining the optimal cell suspension density to enhance the accuracy and efficiency of chromosomal aberrations analysis.MethodsLymphocyte metaphase ...
Chao-Xian Gao +6 more
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