ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis [PDF]
Advanced ScienceThe synaptonemal complex (SC) is essential for accurate homologous chromosome pairing, recombination, and segregation during meiosis. Although several core SC components have been identified in plants, the molecular mechanism coordinating their assembly ...
Miaowei Geng +16 more
doaj +3 more sources
Synaptonemal Complex in Human Biology and Disease [PDF]
Cells, 2023 The synaptonemal complex (SC) is a meiosis-specific multiprotein complex that forms between homologous chromosomes during prophase of meiosis I. Upon assembly, the SC mediates the synapses of the homologous chromosomes, leading to the formation of ...
Elena Llano, Alberto M. Pendás
doaj +2 more sources
Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex [PDF]
Life Science Alliance, 2023 Exchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids.
David E Almanzar +6 more
doaj +2 more sources
Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental Biology, 2023 During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination.
Joaquim Soriano +3 more
doaj +2 more sources
SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis. [PDF]
Cell ProlifThe transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Liu K +16 more
europepmc +2 more sources
Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish [PDF]
Frontiers in Genetics, 2023 Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility.
Jing Wang +10 more
doaj +2 more sources
Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida [PDF]
Open Biology, 2021 Chromosome segregation in eukaryotes is driven by the kinetochore, a macromolecular complex that connects centromeric DNA to microtubules of the spindle apparatus.
Eelco C. Tromer +4 more
doaj +2 more sources
Drosophila COMPASS Complex Subunits Set1 and Ash2 Are Required for Oocyte Determination and Maintenance of the Synaptonemal Complex [PDF]
Journal of Developmental BiologyFemale gametogenesis is orchestrated by dynamic epigenetic modifications. In mammals, SETDB1, a histone H3K9 methyltransferase, is required for proper meiotic progression and early embryonic development.
Brigite Cabrita +2 more
doaj +2 more sources
Unconventional conservation reveals structure-function relationships in the synaptonemal complex [PDF]
eLife, 2021 Functional requirements constrain protein evolution, commonly manifesting in a conserved amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged ...
Lisa E Kursel, Henry D Cope, Ofer Rog
doaj +2 more sources
Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage [PDF]
Nature Communications, 2022 During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via ...
Stéphanie Durand +6 more
doaj +2 more sources