Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex [PDF]
Protein & Cell, 2017 Jianrong Feng +8 more
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Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 [PDF]
Communications Biology, 2021 Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer ...
Sumit Sandhu +8 more
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Kinetic analysis of synaptonemal complex dynamics during meiosis of yeast Saccharomyces cerevisiae reveals biphasic growth and abortive disassembly [PDF]
Frontiers in Cell and Developmental Biology, 2023 The synaptonemal complex (SC) is a dynamic structure formed between chromosomes during meiosis which stabilizes and supports many essential meiotic processes such as pairing and recombination. In budding yeast, Zip1 is a functionally conserved element of
Michael G. Pollard +4 more
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Meiosis in mice without a synaptonemal complex.
PLoS ONE, 2011 The synaptonemal complex (SC) promotes fusion of the homologous chromosomes (synapsis) and crossover recombination events during meiosis. The SC displays an extensive structural conservation between species; however, a few organisms lack SC and execute ...
Anna Kouznetsova +3 more
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Diversification and recurrent adaptation of the synaptonemal complex in Drosophila. [PDF]
PLoS GeneticsThe synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where
Rana Zakerzade +9 more
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Correction: Synaptonemal & CO analyzer: a tool for synaptonemal complex and crossover analysis in immunofluorescence images [PDF]
Frontiers in Cell and Developmental BiologyJoaquim Soriano +3 more
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Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. [PDF]
PLoS Genetics, 2010 Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata.
Yong-Hyun Shin +8 more
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iScience, 2022 Summary: Meiotic prophase I is a prolonged G2 phase that ensures the completion of numerous meiosis-specific chromosome events. During meiotic prophase I, homologous chromosomes undergo synapsis to facilitate meiotic recombination yielding crossovers. It
Nobuhiro Tanno +8 more
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Coupling crossover and synaptonemal complex in meiosis. [PDF]
Genes Dev, 2022 During meiosis, a molecular program induces DNA double-strand breaks (DSBs) and their repair by homologous recombination. DSBs can be repaired with or without crossovers. ZMM proteins promote the repair toward crossover. The sites of DSB repair are also sites where the axes of homologous chromosomes are juxtaposed and stabilized, and where a structure ...
Grey C, de Massy B.
europepmc +4 more sources
Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. [PDF]
PLoS Genetics, 2012 Recent studies in simple model organisms have shown that centromere pairing is important for ensuring high-fidelity meiotic chromosome segregation. However, this process and the mechanisms regulating it in higher eukaryotes are unknown.
C Gaston Bisig +6 more
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