Involvement of synaptonemal complex proteins in sex chromosome segregation during marsupial male meiosis. [PDF]
PLoS Genetics, 2006 Marsupial sex chromosomes break the rule that recombination during first meiotic prophase is necessary to ensure reductional segregation during first meiotic division.
Jesús Page +9 more
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Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals Non-Canonical Anti-Parallel Dimeric Structure of Transverse Filament at the Synaptonemal Complex. [PDF]
PLoS ONE, 2016 The synaptonemal complex protein 1 (SYCP1) is the main structural element of transverse filaments (TFs) of the synaptonemal complex (SC), which is a meiosis-specific complex structure formed at the synapse of homologue chromosomes to hold them together ...
Eun Kyung Seo +4 more
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Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip
Communications Biology, 2022 The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of its ...
James M. Dunce +2 more
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Heterogeneity in conservation of multifunctional partner enzymes with meiotic importance, CDK2 kinase and BRCA1 ubiquitin ligase [PDF]
PeerJ, 2021 The evolution of proteins can be accompanied by changes not only to their amino acid sequences, but also their structural and spatial molecular organization.
Sergey Matveevsky, Tatiana Grishaeva
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Synaptonemal Complexities and Commonalities [PDF]
Molecular Cell, 2003 Formation of synaptonemal complex and high levels of homologous recombination are the hallmarks of meiotic prophase. The relationship between these two processes has been the subject of intense study for nearly 50 years. Recent findings highlight the differences and commonalities of this relationship in different species.
openaire +2 more sources
Synaptonemal complex karyotype of zebrafish [PDF]
Heredity, 2003 Meiotic cells of zebrafish have been prepared to show synaptonemal complexes (SCs) by light and electron microscopy. Completely paired SCs from both spermatocytes and oocytes were measured to produce an SC karyotype. The SC karyotype resembles the somatic karyotype of zebrafish and has no recognisable sex bivalent.
B M N, Wallace, H, Wallace
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PLoS Genetics, 2009 In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the proteins of the recombination ...
Ewelina Bolcun-Filas +7 more
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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2018 Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1
Qianyan Li +8 more
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C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
Nature Communications, 2016 The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and ...
Laura Gómez-H +12 more
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PLoS Genetics, 2020 Meiotic recombination is essential for faithful segregation of homologous chromosomes during gametogenesis. The progression of recombination is associated with dynamic changes in meiotic chromatin structures.
Kazumasa Takemoto +6 more
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