Results 31 to 40 of about 13,512 (241)

Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals Non-Canonical Anti-Parallel Dimeric Structure of Transverse Filament at the Synaptonemal Complex. [PDF]

PLoS ONE, 2016
The synaptonemal complex protein 1 (SYCP1) is the main structural element of transverse filaments (TFs) of the synaptonemal complex (SC), which is a meiosis-specific complex structure formed at the synapse of homologue chromosomes to hold them together ...
Eun Kyung Seo, Jae Young Choi, Jae-Hee Jeong, Yeon-Gil Kim, Hyun Ho Park   +4 more
doaj   +1 more source

Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

Communications Biology, 2022
The X-ray crystal structures of C-terminal mutants of the coiled-coil protein cancer testis antigen TEX12 in combination with modeling of the TEX12 wild-type dimer reveal the protein’s control of its oligomeric state, which resembles assembly of its ...
James M. Dunce, Lucy J. Salmon, Owen R. Davies   +2 more
doaj   +1 more source

Synaptonemal complex karyotype of zebrafish [PDF]

Heredity, 2003
Meiotic cells of zebrafish have been prepared to show synaptonemal complexes (SCs) by light and electron microscopy. Completely paired SCs from both spermatocytes and oocytes were measured to produce an SC karyotype. The SC karyotype resembles the somatic karyotype of zebrafish and has no recognisable sex bivalent.
B M N, Wallace, H, Wallace
openaire   +2 more sources

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]

, 2017
The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D, Komives, Elizabeth A, West, Alan MV   +2 more
core   +2 more sources

Mutation of the mouse Syce1 gene disrupts synapsis and suggests a link between synaptonemal complex structural components and DNA repair.

PLoS Genetics, 2009
In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the proteins of the recombination ...
Ewelina Bolcun-Filas, Emma Hall, Robert Speed, Mary Taggart, Corinne Grey, Bernard de Massy, Ricardo Benavente, Howard J Cooke   +7 more
doaj   +1 more source

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2018
Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1
Qianyan Li, Takamune T Saito, Marina Martinez-Garcia, Alison J Deshong, Saravanapriah Nadarajan, Katherine S Lawrence, Paula M Checchi, Monica P Colaiacovo, JoAnne Engebrecht   +8 more
doaj   +1 more source

Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe [PDF]

, 2006
Peer ...
Estreicher, A., Kohli, J., Loidl, J., Lorenz, A.   +3 more
core   +1 more source

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

Nature Communications, 2016
The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and ...
Laura Gómez-H, Natalia Felipe-Medina, Manuel Sánchez-Martín, Owen R. Davies, Isabel Ramos, Ignacio García-Tuñón, Dirk G. de Rooij, Ihsan Dereli, Attila Tóth, José Luis Barbero, Ricardo Benavente, Elena Llano, Alberto M. Pendas   +12 more
doaj   +1 more source

Errors in chromosome segregation during oogenesis and early embryogenesis [PDF]

, 2010
Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases.
A Dyban, A Kuliev, A Kuliev, A Mantzouratou, A Pujol, AL Barlow, C Gutierrez-Mateo, C Gutierrez-Mateo, C Staessen, C Tease, C Tease, C Tease, C Yuncken, CM Conn, CM Conn, D Wells, D Wells, E Bendsen, E Fragouli, E Fragouli, E Fragouli, E Fragouli, E Iwarsson, EY Cheng, F Pellestor, F Pellestor, G Sher, HE Hall, J Cohen, J Cozzi, JD Delhanty, JD Delhanty, JD Delhanty, JD Delhanty, KT Jones, L Gianaroli, L Gras, L Voullaire, L Voullaire, L Wilton, M Hultén, M Sandalinas, M Simopoulou, MA Hultén, ML Lenzi, NV Kovaleva, P Platteau, PA Almeida, PA Hunt, R Angell, R Mahmood, S Cupisti, S Evsikov, S Mastenbroek, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, S Munné, T Anahory, T Hassold, TR Oliver, Y Verlinsky   +65 more
core   +1 more source

Essential and checkpoint functions of budding yeast ATM and ATR during meiotic prophase are facilitated by differential phosphorylation of a meiotic adaptor protein, Hop1 [PDF]

, 2015
A hallmark of the conserved ATM/ATR signalling is its ability to mediate a wide range of functions utilizing only a limited number of adaptors and effector kinases.
A Alcasabas, A Emili, A Traven, AA Ali, Alastair S. Goldman, Ana Penedos, Anthony L. Johnson, B Argunhan, C Chuang, D Bishop, D Durocher, D Durocher, D Lydall, D Ontoso, D Woltering, DK Bishop, Emily Strong, H Cartagena-Lirola, H Lee, H Niu, H Niu, H Tsubouchi, HY Wu, I Acosta, J Falk, J Harper, J Melo, JA Carballo, JA Carballo, JA Carballo, Jesús A. Carballo, JM Bailis, JP Lao, K Hofmann, L Wan, L Xu, M Shinohara, MB Yaffe, Michael Lichten, NM Hollingsworth, NM Hollingsworth, R Suhandynata, Rita S. Cha, RS Cha, S Gray, T Allers, T de los Santos, T Tougan, T Usui, V Busygina, Y Sanchez, YH Lo   +51 more
core   +11 more sources