Results 31 to 40 of about 6,967 (166)
Dynamic molecular architecture of the synaptonemal complex. [PDF]
Sci Adv, 2020 Abstract During meiosis, pairing between homologous chromosomes is stabilized by the assembly of a protein lattice known as the synaptonemal complex (SC). The SC ensures the formation of crossovers between homologous chromosomes and also regulates their distribution.
Köhler S, Wojcik M, Xu K, Dernburg AF.
europepmc +5 more sources
A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori
G3: Genes, Genomes, Genetics, 2023 Meiosis is usually described as 4 essential and sequential processes: (1) homolog pairing; (2) synapsis, mediated by the synaptonemal complex; (3) crossing over; and (4) segregation.
Youbin Xiang +9 more
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SCF Cdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis
Life Science Alliance, 2021 During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCF Cdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.
Zhihui Zhu +3 more
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A BIRD´S-EYE VIEW OF CHROMOSOMES DURING MEIOTIC PROPHASE I [PDF]
BAG. Journal of Basic and Applied Genetics, 2022 The present review aims to summarize the research carried out in relation to meiosis in birds, especially by observing the protein axes of the chromosomes in prophase I of meiosis. This line of research, initially developed in Argentina, has provided key
Pigozzi M.I.
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Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair
Life Science Alliance, 2018 This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Noriko Hosoya +2 more
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Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling
Molecular Systems Biology, 2013 Genes with common profiles of the presence and absence in disparate genomes tend to function in the same pathway. By mapping all human genes into about 1000 clusters of genes with similar patterns of conservation across eukaryotic phylogeny, we ...
Yuval Tabach +9 more
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Evolutionary history of the mammalian synaptonemal complex [PDF]
Chromosoma, 2016 The synaptonemal complex (SC), a key structure of meiosis that assembles during prophase I, has been initially described 60 years ago. Since then, the structure has been described in many sexually reproducing organisms. However, the SC protein components were characterized in only few model organisms.
Johanna, Fraune +5 more
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Advanced Science, EarlyView.eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu +12 more
wiley +1 more source
Biological Reviews, EarlyView.ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
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A first genetic portrait of synaptonemal complex variation.
PLoS Genetics, 2019 The synaptonemal complex (SC) is a proteinaceous scaffold required for synapsis and recombination between homologous chromosomes during meiosis. Although the SC has been linked to differences in genome-wide crossover rates, the genetic basis of standing ...
Richard J Wang +3 more
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